Issue 8, 2006
From the journal:

Soft Matter

Anion hopping of (and on) functional oligoarginines: from chloroform to cells

Naomi Sakai,*a   Shiroh Futaki*bc  and  Stefan Matile*a  

* Corresponding authors

a Department of Organic Chemistry, University of Geneva, Geneva, Switzerland
E-mail: naomi.sakai@chiorg.unige.ch, stefan.matile@chiorg.unige.ch
Fax: +41 22 379 5123
Tel: +41 22 379 6523

b Institute for Chemical Research, Kyoto University, Kyoto, Japan

c PRESTO, JST, Kyoto, Japan
E-mail: futaki@scl.kyoto-u.ac.jp

Abstract

Rapid progress in the understanding of counteranions as either activators or inactivators of guanidinium-rich macromolecules is summarized. From phase transfer of polyarginine into chloroform to the cytosolic delivery of green-fluorescent proteins or apoptosis-inducing peptides with cell-penetrating peptides, counteranions emerge consistently as the origin of function. A unified view of this “demystified arginine magic” is proposed, focusing on the manipulation of the underlying anion hopping of and on these sticky molecular chameleons according to the principle of Le Chatelier.

Graphical abstract: Anion hopping of (and on) functional oligoarginines: from chloroform to cells

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Article information

DOI
https://doi.org/10.1039/B606955J
Article type
Highlight
Submitted
17 May 2006
Accepted
12 Jun 2006
First published
03 Jul 2006

Soft Matter, 2006,2, 636-641

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Anion hopping of (and on) functional oligoarginines: from chloroform to cells

N. Sakai, S. Futaki and S. Matile, Soft Matter, 2006, 2, 636 DOI: 10.1039/B606955J

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