Issue 46, 2007
From the journal:

Journal of Materials Chemistry

Gd-doped iron-oxide nanoparticles for tumour therapy via magnetic field hyperthermia

Philip Drake,a   Hui-Ju Cho,a   Pei-Shin Shih,a   Chao-Hung Kao,a   Kun-Feng Lee,a   Chien-Hung Kuo,a   Xi-Zhang Linb  and  Yuh-Jiuan Lin*a  

* Corresponding authors

a ITRI, Medical Electronics and Device Tech. Center, Chung Hsing Rd., Hsinchu, Taiwan, ROC
E-mail: yjlin@itri.org.tw
Fax: +886-3-5910047
Tel: +886-3-5912162

b Department of Medicine, National Cheng Kung University, Tainan, Taiwan, ROC

Abstract

Gd-doped iron oxide nanoparticles were developed for use in tumour therapy via magnetic fluid hyperthermia (MFH). The nanoparticle composition was Gd0.02Fe2.98O4 as determined by ICP-AES. TEM image analysis showed the primary particles to be about 13 nm in diameter. The specific power adsorption rate (SAR) determined with a field strength of 246 Oe and 52 kHz was 36 W per gram of Fe. This value is about 4 times higher than the reported SAR values for Fe3O4. The heating rate for the nanoparticles in vivo and the potential for tumour therapy were determined in a mouse model. The mouse models treated with doped iron oxide displayed much slower tumour growth, the tumour doubled its mass after 7 days post-treatment compared to 4 days for those models treated with standard iron oxide or saline solution.

Graphical abstract: Gd-doped iron-oxide nanoparticles for tumour therapy via magnetic field hyperthermia

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Article information

DOI
https://doi.org/10.1039/B711962C
Article type
Paper
Submitted
06 Aug 2007
Accepted
04 Oct 2007
First published
16 Oct 2007

J. Mater. Chem., 2007,17, 4914-4918

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Gd-doped iron-oxide nanoparticles for tumour therapy via magnetic field hyperthermia

P. Drake, H. Cho, P. Shih, C. Kao, K. Lee, C. Kuo, X. Lin and Y. Lin, J. Mater. Chem., 2007, 17, 4914 DOI: 10.1039/B711962C

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