Issue 23, 2008
From the journal:

Journal of Materials Chemistry

Flexible, silver containing nanocomposites for the repair of bone defects: antimicrobial effect against E. coli infection and comparison to tetracycline containing scaffolds†

Oliver D. Schneider,a   Stefan Loher,a   Tobias J. Brunner,a   Patrick Schmidlinb  and  Wendelin J. Stark*a  

* Corresponding authors

a Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, HCI E107, Zurich, Switzerland
E-mail: wendelin.stark@chem.ethz.ch
Fax: +41 44 633 10 83
Tel: +41 44 632 09 80

b Clinic for Preventive Dentistry, Periodontology and Cariology, University of Zurich, Zurich, Switzerland

Abstract

Bone regeneration in infected tissue or areas with high bacteria concentrations such as the oral cavity requires combining disinfection with biomaterial properties. Classical antibiotics typically provide excellent short term protection against re-infection of a defect but are typically washed out of an operation site within days. The present work investigates the use of silver on amorphous tricalcium phosphate (TCP) nanoparticles for electrospun, highly porous poly(lactide-co-glyclolide) (PLGA) fibrous composites. In vitro bioactivity tests of the wool-like composite PLGA/Ag-TCP (80 : 20) containing 0.5 wt% silver showed rapid hydroxyapatite deposition on the nanocomposite within 2 days. Antibacterial tests using E. coli demonstrated a strongly prolonged antibacterial effect of the scaffolds containing finely dispersed silver on TCP if compared to current clinically used methods based on soaking the scaffolds with a tetracycline solution prior to implantation.

Graphical abstract: Flexible, silver containing nanocomposites for the repair of bone defects: antimicrobial effect against E. coli infection and comparison to tetracycline containing scaffolds

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Article information

DOI
https://doi.org/10.1039/B800522B
Article type
Paper
Submitted
11 Jan 2008
Accepted
04 Apr 2008
First published
24 Apr 2008

J. Mater. Chem., 2008,18, 2679-2684

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Flexible, silver containing nanocomposites for the repair of bone defects: antimicrobial effect against E. coli infection and comparison to tetracycline containing scaffolds

O. D. Schneider, S. Loher, T. J. Brunner, P. Schmidlin and W. J. Stark, J. Mater. Chem., 2008, 18, 2679 DOI: 10.1039/B800522B

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