Issue 2, 2009
From the journal:

Lab on a Chip

Label-free determination of protein–surface interaction kinetics by ionic conductance inside a nanochannel

Nicolas F. Y. Durand*a  and  Philippe Renauda  

* Corresponding authors

a Microsystems Laboratory, STI-LMIS, EPFL, Lausanne, Switzerland

Abstract

We have developed a label-free conductometric platform for the rapid measurement of kinetics parameters for the adsorption and desorption of proteins on surfaces. Adsorbed Bovine Serum Albumin (BSA) has been detected electrically with response times in the minute range, and kinetic models were elaborated and compared to the measurements. The device presents similar characteristics to Surface Plasmon Resonance (SPR) immunosensors, but takes advantage of a simpler, low-cost electronic measurement unit.

Graphical abstract: Label-free determination of protein–surface interaction kinetics by ionic conductance inside a nanochannel

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Article information

DOI
https://doi.org/10.1039/B811006A
Article type
Paper
Submitted
28 Jun 2008
Accepted
02 Oct 2008
First published
04 Nov 2008

Lab Chip, 2009,9, 319-324

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Label-free determination of protein–surface interaction kinetics by ionic conductance inside a nanochannel

N. F. Y. Durand and P. Renaud, Lab Chip, 2009, 9, 319 DOI: 10.1039/B811006A

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