Issue 4, 2009
From the journal:

Lab on a Chip

Spectroscopic characterisation and manipulation of arrays of sub-picolitre aerosol droplets

Jason R. Butler,a   Jon B. Wills,a   Laura Mitchem,a   Daniel R. Burnham,bc   David McGloinb  and  Jonathan P. Reid*a  

* Corresponding authors

a School of Chemistry, University of Bristol, Bristol, UK

b Electronic Engineering and Physics Division, University of Dundee, Dundee DD1, UK

c SUPA, School of Physics and Astronomy, University of St. Andrews, St. Andrews, UK

Abstract

Arrays of optically tweezed aerosol droplets, each of sub-picolitre volume, are manipulated by holographic optical tweezers and characterised by cavity enhanced Raman spectroscopy. A spatial light modulator is employed to generate arrays of optical traps from a single laser beam and to control the array dimensions and relative trap positions. Comparative hygroscopicity measurements are performed concurrently on five trapped droplets by monitoring the evolving size of each droplet. This is extended to the controlled coalescence of an array of droplets accompanied by spectroscopic measurements. These data represent the first ever simultaneous measurements of the evolving composition and size of an array of aerosol droplets. We consider the possibility of using aerosol arrays as a platform for studying chemical reactions in sub-picolitre volumes, exploiting the versatility of aerosol arrays for performing optical digital microfluidic operations accompanied by micro-total analysis.

Graphical abstract: Spectroscopic characterisation and manipulation of arrays of sub-picolitre aerosol droplets

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Article information

DOI
https://doi.org/10.1039/B814545H
Article type
Paper
Submitted
20 Aug 2008
Accepted
23 Oct 2008
First published
19 Nov 2008

Lab Chip, 2009,9, 521-528

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Spectroscopic characterisation and manipulation of arrays of sub-picolitre aerosol droplets

J. R. Butler, J. B. Wills, L. Mitchem, D. R. Burnham, D. McGloin and J. P. Reid, Lab Chip, 2009, 9, 521 DOI: 10.1039/B814545H

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