Issue 8, 2009
From the journal:

Chemical Society Reviews

Molecular assembly and application of biomimetic microcapsules

Qiang He,ab   Yue Cuia  and  Junbai Li*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences (BNLMS), International Joint Lab, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China
E-mail: jbli@iccas.ac.cn
Fax: +86 10 82612629
Tel: +86 10 82614087

b Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, D-14476 Golm/Potsdam, Germany

Abstract

The assembly of multifunctional biomimetic microcapsules at the molecular level is of tremendous interest for biophysical research and the biomedical field. Among the available molecular assembly techniques, layer-by-layer assembly has attracted extensive attention for the fabrication of biomimetic microcapsules because it possesses engineered features including size, shape, thickness, composition and permeation, and the capability of incorporating different types of biomolecules. In this tutorial review, we highlight how biomimetic microcapsules can be fabricated by directly applying lipids and proteins as assembly pairs and how layer-by-layer assembled polyelectrolyte microcapsules can be interfaced with biological components such as phospholipid membranes and proteins. The applications of these biomimetic microcapsules in drug delivery, biosensors, and hybrid nanodevices are also addressed.

Graphical abstract: Molecular assembly and application of biomimetic microcapsules

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Article information

DOI
https://doi.org/10.1039/B816475B
Article type
Tutorial Review
Submitted
26 Feb 2009
First published
08 May 2009

Chem. Soc. Rev., 2009,38, 2292-2303

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Molecular assembly and application of biomimetic microcapsules

Q. He, Y. Cui and J. Li, Chem. Soc. Rev., 2009, 38, 2292 DOI: 10.1039/B816475B

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