Issue 12, 2009
From the journal:

Chemical Society Reviews

Peptide-based fluorescent biosensors

Elena Pazos,a   Olalla Vázquez,a   José L. Mascareñas*a  and  M. Eugenio Vázquez*a  

* Corresponding authors

a Departamento de Química Orgánica. Universidade de Santiago de Compostela, Av. de las Ciencias sn, Campus Sur. 15782 Santiago de Compostela, Spain
E-mail: eugenio.vazquez@usc.es
Fax: 34 981 595 012
Tel: 34 981 563 100 ext. 14405

Abstract

The use of fluorescent techniques in biological research is widespread. Many of the techniques rely on the use of fluorescent genetically-encoded tags (namely GFP and its different variants), but small molecules and nanoparticle-based approaches are being increasingly used. Peptides, owing to their modular nature, synthetic accessibility and biomolecular recognition potential, offer unique possibilities for the development of efficient and selective fluorescent sensors. In this tutorial review we present several of the strategies that have been used to develop fluorescent-based peptide sensors and discuss selected applications to biological problems.

Graphical abstract: Peptide-based fluorescent biosensors

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Article information

DOI
https://doi.org/10.1039/B908546G
Article type
Tutorial Review
Submitted
29 Apr 2009
First published
11 Aug 2009

Chem. Soc. Rev., 2009,38, 3348-3359

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Peptide-based fluorescent biosensors

E. Pazos, O. Vázquez, J. L. Mascareñas and M. Eugenio Vázquez, Chem. Soc. Rev., 2009, 38, 3348 DOI: 10.1039/B908546G

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