Issue 20, 2009
From the journal:

Lab on a Chip

Chemical imaging of microfluidic flows using ATR-FTIR spectroscopy

K. L. Andrew Chan,a   Shelly Gulati,bc   Joshua B. Edel,bc   Andrew J. de Mellob  and  Sergei G. Kazarian*a  

* Corresponding authors

a Department of Chemical Engineering, Imperial College London, South Kensington Campus, London, United Kingdom
E-mail: s.kazarian@imperial.ac.uk
Tel: +44 (0)20 7594 5574

b Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London, United Kingdom

c Institute of Biomedical Engineering, Imperial College London, Exhibition Road, South Kensington, London, United Kingdom

Abstract

Elucidating the chemical composition of microfluidic flows is crucial in both understanding and optimising reactive processes within small-volume environments. Herein we report the implementation of a novel detection methodology based on Attenuated Total Reflection (ATR)–Fourier Transform Infra-Red (FTIR) spectroscopic imaging using an infrared focal plane array detector for microfluidic applications. The method is based on the combination of an inverted prism-shape ATR crystal with a poly(dimethylsiloxane)-based microfluidic mixing device. To demonstrate the efficacy of this approach, we report the direct measurement and imaging of the mixing of two liquids of different viscosities and the imaging and mixing of H2O and D2O with consecutive H/D isotope exchange. This chemically specific imaging approach allows direct analysis of fluid composition as a function of spatial position without the use of added labels or dyes, and can be used to study many processes in microfluidics ranging from reactions to separations.

Graphical abstract: Chemical imaging of microfluidic flows using ATR-FTIR spectroscopy

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Article information

DOI
https://doi.org/10.1039/B909573J
Article type
Paper
Submitted
14 May 2009
Accepted
09 Jul 2009
First published
22 Jul 2009

Lab Chip, 2009,9, 2909-2913

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Chemical imaging of microfluidic flows using ATR-FTIR spectroscopy

K. L. A. Chan, S. Gulati, J. B. Edel, A. J. de Mello and S. G. Kazarian, Lab Chip, 2009, 9, 2909 DOI: 10.1039/B909573J

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