Issue 45, 2009
From the journal:

Chemical Communications

Enhanced resistance of DNAnanostructures to enzymatic digestion†

Jung-Won Keuma  and  Harry Bermudez*b  

* Corresponding authors

a Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA

b Department of Polymer Science and Engineering, University of Massachusetts, Amherst, MA, USA
E-mail: bermudez@polysci.umass.edu
Fax: +1 413 545 0082
Tel: +1 413 577 1413

Abstract

The ability of nucleases to perform their catalytic functions depends on the sequence and structural features of target DNA substrates. Due to their size and shape, several DNA tetrahedra are resistant to the action of specific and non-specific nucleases. Such enhanced stability is a key requirement for DNAnanostructures to be useful as delivery vehicles.

Graphical abstract: Enhanced resistance of DNAnanostructures to enzymatic digestion

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Article information

DOI
https://doi.org/10.1039/B917661F
Article type
Communication
Submitted
27 Aug 2009
Accepted
23 Sep 2009
First published
13 Oct 2009

Chem. Commun., 2009, 7036-7038

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Enhanced resistance of DNAnanostructures to enzymatic digestion

J. Keum and H. Bermudez, Chem. Commun., 2009, 7036 DOI: 10.1039/B917661F

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