Issue 29, 2010
From the journal:

Journal of Materials Chemistry

Gold nanoparticles: dispersibility in biological media and cell-biological effect

Dirk Mahl,a   Christina Greulich,b   Wolfgang Meyer-Zaika,a   Manfred Köller*b  and  Matthias Epple*a  

* Corresponding authors

a Inorganic Chemistry and Center for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitätsstr. 5–7, Essen, Germany
E-mail: matthias.epple@uni-due.de

b Bergmannsheil University Hospital/Surgical Research, Ruhr-University Bochum, Bürkle-de-la-Camp-Platz 1, Bochum, Germany
E-mail: manfred.koeller@rub.de

Abstract

Spherical gold nanoparticles with a hydrodynamic diameter between 25 and 37 nm were prepared and stabilised with poly(N-vinylpyrrolidone) (PVP) or tris(sodium-m-sulfonatophenyl)phosphine (TPPTS). They were subjected to different cell culture media, e.g. pure RPMI, RPMI containing up to 10% of fetal calf serum (FCS), and RPMI containing up to 10% of bovine serum albumin (BSA), and the rate of agglomeration was studied by dynamic light scattering. In pure RPMI, a strong agglomeration was observed whereas in the RPMI–FCS and RPMI–BSA mixtures the particles remained well dispersed above 1 wt% protein concentration. The effect of PVP-stabilised gold nanoparticles on human mesenchymal stem cells (hMSC) was studied as well. No significant influence on the viability and chemotaxis was observed after incubation of hMSC with gold nanoparticles. However, gold nanoparticles induced the activation of hMSC as indicated by the release of IL-6 and IL-8.

Graphical abstract: Gold nanoparticles: dispersibility in biological media and cell-biological effect

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Article information

DOI
https://doi.org/10.1039/C0JM01071E
Article type
Paper
Submitted
16 Apr 2010
Accepted
05 Jun 2010
First published
25 Jun 2010

J. Mater. Chem., 2010,20, 6176-6181

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Gold nanoparticles: dispersibility in biological media and cell-biological effect

D. Mahl, C. Greulich, W. Meyer-Zaika, M. Köller and M. Epple, J. Mater. Chem., 2010, 20, 6176 DOI: 10.1039/C0JM01071E

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