Issue 19, 2010
From the journal:

Lab on a Chip

Separation and metrology of nanoparticles by nanofluidic size exclusion

Samuel M. Stavis,*a   Jon Geista  and  Michael Gaitana  

* Corresponding authors

a National Institute of Standards and Technology—Semiconductor Electronics Division, 100 Bureau Drive, Stop 8120, Gaithersburg, Maryland, USA
E-mail: sstavis@nist.gov, gaitan@nist.gov, jon.geist@nist.gov
Tel: +1 (301) 975-3246

Abstract

A nanofluidic technology for the on-chip size separation and metrology of nanoparticles is demonstrated. A nanofluidic channel was engineered with a depth profile approximated by a staircase function. Numerous stepped reductions in channel depth were used to separate a bimodal mixture of nanoparticles by nanofluidic size exclusion. Epifluorescence microscopy was used to map the size exclusion positions of individual nanoparticles to corresponding channel depths, enabling measurement of the nanoparticle size distributions and validation of the size separation mechanism.

Graphical abstract: Separation and metrology of nanoparticles by nanofluidic size exclusion

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Article information

DOI
https://doi.org/10.1039/C0LC00029A
Article type
Technical Note
Submitted
14 May 2010
Accepted
09 Jul 2010
First published
11 Aug 2010

Lab Chip, 2010,10, 2618-2621

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Separation and metrology of nanoparticles by nanofluidic size exclusion

S. M. Stavis, J. Geist and M. Gaitan, Lab Chip, 2010, 10, 2618 DOI: 10.1039/C0LC00029A

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