A turn-on PET fluorescence sensor for imaging Cu2+ in living cells

Guangjie He; Xiuwen Zhao; Xiaolin Zhang; Hongjun Fan; Shuo Wu; Huaqiang Li; Cheng He; Chunying Duan

doi:10.1039/C0NJ00132E

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A turn-on PET fluorescence sensor for imaging Cu²⁺ in living cells†

Guangjie He,^a Xiuwen Zhao,^a Xiaolin Zhang,^a Hongjun Fan,*^b Shuo Wu,^a Huaqiang Li,^a Cheng He^a and Chunying Duan*^a

Author affiliations

* Corresponding authors

^a State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, China
E-mail: cyduan@dlut.edu.cn

^b State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Dalian, China
E-mail: fanhj@dicp.ac.cn

Abstract

By the incorporation of coumarin fluorophores within the benzyldihydrazone moiety and by carefully adjusting the redox potential of the fluorophore and its excited state energy, one of the brightest Cu²⁺-binding sensors in aqueous media was achieved and could be used for the detection of Cu²⁺ in living cells.

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Supplementary files

Experimental details and additional spectroscopic data PDF (510K)

Article information

DOI: https://doi.org/10.1039/C0NJ00132E
Article type: Letter
Submitted: 18 Feb 2010
Accepted: 04 Mar 2010
First published: 30 Mar 2010

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New J. Chem., 2010,34, 1055-1058

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A turn-on PET fluorescence sensor for imaging Cu²⁺ in living cells

G. He, X. Zhao, X. Zhang, H. Fan, S. Wu, H. Li, C. He and C. Duan, New J. Chem., 2010, 34, 1055 DOI: 10.1039/C0NJ00132E

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