Issue 20, 2011
From the journal:

Analyst

Insulin-binding aptamer-conjugated graphene oxide for insulin detection†

Ying Pu,‡ab   Zhi Zhu,‡b   Da Han,‡b   Huixia Liu,*a   Jun Liu,ab   Jie Liao,a   Kejing Zhangab  and  Weihong Tan*b  

* Corresponding authors

a Xiangya Hospital, Central South University, P.O. Box 190, Changsha, Hunan, China
E-mail: lhx900@yahoo.com.cn

b Department of Chemistry and Department of Physiology and Functional Genomics, University of Florida, Gainesville, Florida, USA
E-mail: tan@chem.ufl.edu

Abstract

This paper describes a simple and sensitive aptamer/graphene oxide (GO) based assay for insulin detection. GO can protect DNA from nuclease cleavage, but aptamers can be detached from the GO surface by specific target binding. This exposes the aptamers to enzymatic cleavage and releases the target for a new cycle. Cycling of targets leads to significant signal amplification and low LOD.

Graphical abstract: Insulin-binding aptamer-conjugated graphene oxide for insulin detection

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Article information

DOI
https://doi.org/10.1039/C1AN15407A
Article type
Communication
Submitted
17 May 2011
Accepted
27 Jul 2011
First published
26 Aug 2011

Analyst, 2011,136, 4138-4140

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Insulin-binding aptamer-conjugated graphene oxide for insulin detection

Y. Pu, Z. Zhu, D. Han, H. Liu, J. Liu, J. Liao, K. Zhang and W. Tan, Analyst, 2011, 136, 4138 DOI: 10.1039/C1AN15407A

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