Issue 15, 2011
From the journal:

Chemical Communications

A specific and sensitive method for detection of hypochlorous acid for the imaging of microbe-induced HOCl production†

Xiaoqiang Chen,‡a   Kyung-Ah Lee,‡b   Eun-Mi Ha,c   Kyung Mi Lee,ad   You Yeong Seo,e   Han Kyoung Choi,e   Ha Na Kim,a   Min Jung Kim,a   Chun-Seok Cho,e   Soo Young Lee,de   Won-Jae Lee*b  and  Juyoung Yoon*ad  

* Corresponding authors

a Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120-750, Korea
E-mail: jyoon@ewha.ac.kr
Fax: +82 2-3277-3419
Tel: +82 2-3277-2400

b School of Biological Science and National Creative Research Initiative Center for Symbiosystem, Seoul National University, Seoul, Korea
E-mail: lwj@snu.ac.kr

c College of Pharmacy, Catholic University of Daegu, Daegu 712-702, Korea

d Department of Bioinspired Science, Ewha Womans University, Seoul 120-750, Korea

e Department of Life Science and Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul 120-750, Korea

Abstract

A specific and sensitive fluorescence-based method was developed for the imaging of microbe-induced HOCl production. Furthermore, we demonstrate dual oxidase (DUOX)-mediated HOCl generation in the mucosa of live animals providing a novel insight into mucosal innate immunity.

Graphical abstract: A specific and sensitive method for detection of hypochlorous acid for the imaging of microbe-induced HOCl production

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Article information

DOI
https://doi.org/10.1039/C1CC10589B
Article type
Communication
Submitted
30 Jan 2011
Accepted
28 Feb 2011
First published
14 Mar 2011

Chem. Commun., 2011,47, 4373-4375

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A specific and sensitive method for detection of hypochlorous acid for the imaging of microbe-induced HOCl production

X. Chen, K. Lee, E. Ha, K. M. Lee, Y. Y. Seo, H. K. Choi, H. N. Kim, M. J. Kim, C. Cho, S. Y. Lee, W. Lee and J. Yoon, Chem. Commun., 2011, 47, 4373 DOI: 10.1039/C1CC10589B

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