Issue 9, 2011
From the journal:

Chemical Society Reviews

Towards mild metal-catalyzed C–H bond activation

Joanna Wencel-Delord,a   Thomas Dröge,a   Fan Liua  and  Frank Glorius*a  

* Corresponding authors

a Westfälische Wilhelms-Universität Münster, Organisch-Chemisches Institut, Corrensstrasse 40, 48149 Münster, Germany
E-mail: glorius@uni-muenster.de
Fax: +49 251 8333202
Tel: +49 251 8333248

Abstract

Functionalizing traditionally inert carbon–hydrogen bonds represents a powerful transformation in organic synthesis, providing new entries to valuable structural motifs and improving the overall synthetic efficiency. C–H bond activation, however, often necessitates harsh reaction conditions that result in functional group incompatibilities and limited substrate scope. An understanding of the reaction mechanism and rational design of experimental conditions have led to significant improvement in both selectivity and applicability. This critical review summarizes and discusses endeavours towards the development of mild C–H activation methods and wishes to trigger more research towards this goal. In addition, we examine select examples in complex natural product synthesis to demonstrate the synthetic utility of mild C–H functionalization (84 references).

Graphical abstract: Towards mild metal-catalyzed C–H bond activation

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Article information

DOI
https://doi.org/10.1039/C1CS15083A
Article type
Critical Review
Submitted
30 Mar 2011
First published
10 Jun 2011

Chem. Soc. Rev., 2011,40, 4740-4761

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Towards mild metal-catalyzed C–H bond activation

J. Wencel-Delord, T. Dröge, F. Liu and F. Glorius, Chem. Soc. Rev., 2011, 40, 4740 DOI: 10.1039/C1CS15083A

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