Issue 25, 2011
From the journal:

Journal of Materials Chemistry

Monodisperse mesoporous cobalt ferrite nanoparticles: synthesis and application in targeted delivery of antitumor drugs†

Sasmita Mohapatra,*a   Smruti R. Rout,a   Swatilekha Maiti,b   Tapas K. Maitib  and  Asit B. Pandac  

* Corresponding authors

a Department of Chemistry, National Institute of Technology, Rourkela, India
E-mail: sasmitam@nitrkl.ac.in
Fax: +91-661-2462651
Tel: +91-661-2462661

b Department of Biotechnology, Indian Institute of Technology, Kharagpur, India

c Central Salt and Marine Chemicals Research Institute, Bhavnagar, Gujurat, India

Abstract

A multifunctional folic acid decorated superparamagnetic mesoporous CoFe2O4 based nanocarrier with the particle size of 35–40 nm was synthesized by a simple method. The particles show excellent aqueous dispersion stability in physiological pH without any deterioration in hydrodynamic size and zetapotential. The cytotoxicity and internalization efficiency of these nanocarriers have been evaluated on folate receptor overexpressed HeLa cells. Fluorescent molecule RITC and antitumor agents such as methotrexate and doxorubicin were successfully attached to the surface amine groups following simple organic coupling reactions thus endowing the nanoparticle with therapeutic and optical properties. These drug loaded nanoagents exhibit elevated cytotoxicity and induce apoptosis in HeLa cells.

Graphical abstract: Monodisperse mesoporous cobalt ferrite nanoparticles: synthesis and application in targeted delivery of antitumor drugs

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Article information

DOI
https://doi.org/10.1039/C1JM10732A
Article type
Paper
Submitted
18 Feb 2011
Accepted
15 Apr 2011
First published
27 May 2011

J. Mater. Chem., 2011,21, 9185-9193

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Monodisperse mesoporous cobalt ferrite nanoparticles: synthesis and application in targeted delivery of antitumor drugs

S. Mohapatra, S. R. Rout, S. Maiti, T. K. Maiti and A. B. Panda, J. Mater. Chem., 2011, 21, 9185 DOI: 10.1039/C1JM10732A

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