Facilitative functionalization of cyanine dye by an on–off–on fluorescent switch for imaging of H2O2 oxidative stress and thiols reducing repair in cells and tissues

Fabiao Yu; Peng Li; Ping Song; Bingshuai Wang; Jianzhang Zhao; Keli Han

doi:10.1039/C2CC30985H

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Facilitative functionalization of cyanine dye by an on–off–on fluorescent switch for imaging of H₂O₂ oxidative stress and thiols reducing repair in cells and tissues†

Fabiao Yu,^a Peng Li,^b Ping Song,^b Bingshuai Wang,^b Jianzhang Zhao^a and Keli Han*^b

Author affiliations

* Corresponding authors

^a School of Chemical Engineering, Dalian University of Technology, 2 Linggong Road, Dalian 116024, P.R. China
E-mail: yufabiao@163.com

^b State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, CAS, P.R. China
E-mail: klhan@dicp.ac.cn

Abstract

We presented the design, synthesis, spectroscopy, and biological applications of DA–Cy, an on–off–on fluorescent probe to monitor H₂O₂ oxidative stress and thiols reducing repair in living cells and tissues simply and directly.

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Article information

DOI: https://doi.org/10.1039/C2CC30985H
Article type: Communication
Submitted: 10 Feb 2012
Accepted: 20 Mar 2012
First published: 21 Mar 2012

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Chem. Commun., 2012,48, 4980-4982

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Facilitative functionalization of cyanine dye by an on–off–on fluorescent switch for imaging of H₂O₂ oxidative stress and thiols reducing repair in cells and tissues

F. Yu, P. Li, P. Song, B. Wang, J. Zhao and K. Han, Chem. Commun., 2012, 48, 4980 DOI: 10.1039/C2CC30985H

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Chemical Communications