The reaction of uranyl and lanthanide (Nd, Dy, Er, Yb) nitrates with 1,2-ethanedisulfonate (EDS²⁻) and cucurbit[6]uril (CB6) under hydrothermal conditions gave the heterometallic complexes [(UO₂)₄Nd₂(EDS)₄(OH)₄(CB6)(H₂O)₁₆]·2NO₃·8H₂O (1) and [(UO₂)₂Ln_1.5(EDS)₂(OH)₂(NO₃)_1.5(CB6)(H₂O)_7.5][(UO₂)₂(EDS)-(OH)₂(H₂O)₄]·NO₃·5.5H₂O with Ln = Dy (2), Er (3) and Yb (4), which have been crystallographically characterized. In all these complexes, one EDS²⁻ ligand is bound to one uranyl and one lanthanide ion through its two monodentate sulfonate groups; the uranyl ion is further part of a bis(hydroxide)-bridged dinuclear unit, while the lanthanide ion is complexed by a CB6 molecule. Ribbon-like one-dimensional assemblies are formed in all cases, with complexes 2–4 differing from 1 by the presence of an additional [(UO₂)₂(EDS)(OH)₂(H₂O)₄] neutral polymeric chain hydrogen bonded to the mixed species.