Issue 45, 2012
From the journal:

Journal of Materials Chemistry

Porous ZnO nanorod for targeted delivery of doxorubicin: in vitro and in vivo response for therapeutic applications†

Shouvik Mitra,a   Subia B.,b   Prasun Patra,a   Sourov Chandra,c   Nitai Debnath,a   Sumistha Das,a   Rahul Banerjee,d   Subhas C. Kundu,b   Panchanan Pramanik*c  and  Arunava Goswami*a  

* Corresponding authors

a AERU, Biological Sciences Division, Indian Statistical Institute, Kolkata, India
E-mail: srabanisopanarunava@gmail.com, shouvik.14@gmail.com

b Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur, India

c Nanomaterials laboratory, Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, India
E-mail: pramanik1946@gmail.com, sourov.chem@gmail.com

d Physical/Materials Chemistry Division, National Chemical Laboratory, Pune, India

Abstract

Cancer cell specific targeted delivery (TDD) by porous nanocarrier is on a high role. Here in a simple route for the synthesis of porous ZnO nanorods (ZnO) has been demonstrated. ZnO expressed very high surface area of 305.14 m2 g−1 (SBET) and uniformly distributed pores of 5 nm. In continuation ZnO has been fabricated with 3-aminophosphonic acid followed by folic acid to yield folate conjugated porous ZnO nanorod (ZnO-FA). High surface area, uniformly distributed pores on its surface make the nanocarrier suitable for high drug loading (88%) of the anticancer drug doxorubicin (DOX). A pH triggered drug release was observed with minimum release in pathophysical conditions. In vitro efficacy of DOX loaded ZnO-FA (ZnO-FA-DOX) has been evaluated against breast cancer cells MDA-MB-231, which is not possible alone by DOX or ZnO-FA. Targeted scaffold with pendant –NH2 group has been covalently bonded with fluorescent dye (RITC) for cellular uptake and imaging studies in MDA-MB-231 cells; the possible pathway for cancer regression has also been evaluated. Even in vivo acute and intravenous toxicological evaluation on murine model system complemented biocompatibility of ZnO-FA in TDD. All together we have collaged a template free synthesis of porous ZnO nanorod, successful targeting on to cancer cells, high drug loading, pH triggered drug release, in vitro efficacy of ZnO-FA-DOX against MDA-MB-231 cells and in vivo compatibility as well. We envisioned the future prospect of porous ZnO nanostructures in TDD.

Graphical abstract: Porous ZnO nanorod for targeted delivery of doxorubicin: in vitro and in vivo response for therapeutic applications

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Article information

DOI
https://doi.org/10.1039/C2JM35013K
Article type
Paper
Submitted
27 Jul 2012
Accepted
01 Oct 2012
First published
01 Oct 2012

J. Mater. Chem., 2012,22, 24145-24154

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Porous ZnO nanorod for targeted delivery of doxorubicin: in vitro and in vivo response for therapeutic applications

S. Mitra, S. B., P. Patra, S. Chandra, N. Debnath, S. Das, R. Banerjee, S. C. Kundu, P. Pramanik and A. Goswami, J. Mater. Chem., 2012, 22, 24145 DOI: 10.1039/C2JM35013K

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