Issue 10, 2012

New potential prodrugs of aciclovir using calix[4]arene as a lipophilic carrier: synthesis and drug-release studies at the air–water interface

Abstract

Two tetra-p-tert-butyl-calix[4]arene species bearing one or two anti-HSV aciclovir units tethered via carbodiester linkages at the lower rim were synthesized as possible antiviral prodrugs. The amphiphilic properties of these derivatives were studied using Langmuir balance at the air–water and air–carbonate buffer interfaces; the monolayers formed were stable on both subphases. Monolayers formed with these molecules on a carbonate buffer subphase at pH 10 and 37 °C were then used for monitoring hydrolysis of the diester linkage. The release of free aciclovir of around 30% in 3 days was observed with both derivatives, as shown with HPLC.

Graphical abstract: New potential prodrugs of aciclovir using calix[4]arene as a lipophilic carrier: synthesis and drug-release studies at the air–water interface

Supplementary files

Article information

Article type
Paper
Submitted
30 Apr 2012
Accepted
20 Jul 2012
First published
23 Jul 2012

New J. Chem., 2012,36, 2060-2069

New potential prodrugs of aciclovir using calix[4]arene as a lipophilic carrier: synthesis and drug-release studies at the air–water interface

G. Sautrey, I. Clarot, E. Rogalska and J. Regnouf-de-Vains, New J. Chem., 2012, 36, 2060 DOI: 10.1039/C2NJ40338B

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