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β-Cyclodextrin polymer nanoparticles as carriers for doxorubicin and artemisinin: a spectroscopic and photophysical study

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Abstract

The association of doxorubicin (DOX) and artemisinin (ART) to a β-CyD-epichlorohydrin crosslinked polymer (pβ-CyD), organized in nanoparticles of ca. 15 nm size, was investigated in neutral aqueous medium by circular dichroism (CD), UV-vis absorption and fluorescence. The stability constants and the absolute CD spectra of the drug complexes were determined by global analysis of multiwavelength data from spectroscopic titrations. The polymer pβ-CyD proved able to disrupt the DOX dimer when the latter is the predominant form of DOX in solution. The spectroscopic and photophysical properties of the complexes evidenced an alcohol-like environment for ART and an improved inherent emission ability for DOX in the nanoparticle frame.

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  1. Istituto per la Sintesi Organica e la Fotoreattività, ISOF-CNR, via P. Gobetti 101, 40129, Bologna, Italy

    Resmi Anand, Francesco Manoli, Ilse Manet & Sandra Monti

  2. Université Paris-Sud, UMR CNRS 8612, 92296, Chatenay Malabry, France

    Samia Daoud-Mahammed, Valentina Agostoni & Ruxandra Gref

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  1. Resmi Anand
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  2. Francesco Manoli
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Anand, R., Manoli, F., Manet, I. et al. β-Cyclodextrin polymer nanoparticles as carriers for doxorubicin and artemisinin: a spectroscopic and photophysical study. Photochem Photobiol Sci 11, 1285–1292 (2012). https://doi.org/10.1039/c2pp25014d

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