Issue 29, 2013
From the journal:

Chemical Communications

The Pauson–Khand reaction of medium sized trans-cycloalkenes†

Agustí Lledó,*a   Aida Fuster,a   Marc Revés,a   Xavier Verdaguerab  and  Antoni Riera*ab  

* Corresponding authors

a Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, 08028 Barcelona, Spain
E-mail: agusti.lledo@irbbarcelona.org, antoni.riera@irbbarcelona.org
Fax: +34 934037095
Tel: +34 934037093

b Departament de Química Orgánica, Universitat de Barcelona, Martí i Franqués 1–11, 08028 Barcelona, Spain

Abstract

Medium sized trans-cycloalkenes are unusually reactive in the intermolecular Pauson–Khand reaction (PKR) with regard to typical monocyclic alkenes. This is due to the ring strain imparted by the E stereochemistry. The PKR of these alkenes offers a modular, regioselective and straightforward entry to trans fused [n.3.0] bicyclic scaffolds (n = 6–8).

Graphical abstract: The Pauson–Khand reaction of medium sized trans-cycloalkenes

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Article information

DOI
https://doi.org/10.1039/C3CC41005F
Article type
Communication
Submitted
05 Feb 2013
Accepted
26 Feb 2013
First published
26 Feb 2013

Chem. Commun., 2013,49, 3055-3057

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The Pauson–Khand reaction of medium sized trans-cycloalkenes

A. Lledó, A. Fuster, M. Revés, X. Verdaguer and A. Riera, Chem. Commun., 2013, 49, 3055 DOI: 10.1039/C3CC41005F

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