Functionalised TiO2 nanoparticles deliver oligo-histidine and avidin tagged biomolecules simultaneously into the cell

Batakrishna Jana; Goutam Mondal; Atanu Biswas; Indrani Chakraborty; Surajit Ghosh

doi:10.1039/C3RA41068D

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Functionalised TiO₂nanoparticles deliver oligo-histidine and avidin tagged biomolecules simultaneously into the cell†

Batakrishna Jana,^a Goutam Mondal,^a Atanu Biswas,^a Indrani Chakraborty^a and Surajit Ghosh*^a

Author affiliations

* Corresponding authors

^a Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4 Raja S. C. Mullick Road, Jadavpur, Kolkata-700032, West Bengal, India
E-mail: sghosh@iicb.res.in
Fax: +91-33-2473-5197/0284
Tel: +91-33-2499-5872

Abstract

The development of multifunctional, biocompatible nanoparticles is essential for delivering drugs and biomolecules into the cell. Here, we have functionalised TiO₂ nanoparticles with tris-(nitrilo trisacetic acid) (Tris-NTA) and biotin, by covalent surface functionalisation. This biocompatible nanoparticle is non-cytotoxic and can deliver both oligo-histidine and avidin conjugated biomolecules simultaneously into the cell.

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Article information

DOI: https://doi.org/10.1039/C3RA41068D
Article type: Communication
Submitted: 05 Mar 2013
Accepted: 11 Apr 2013
First published: 12 Apr 2013

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RSC Adv., 2013,3, 8215-8219

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Functionalised TiO₂ nanoparticles deliver oligo-histidine and avidin tagged biomolecules simultaneously into the cell

B. Jana, G. Mondal, A. Biswas, I. Chakraborty and S. Ghosh, RSC Adv., 2013, 3, 8215 DOI: 10.1039/C3RA41068D

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