Issue 15, 2013
From the journal:

Journal of Materials Chemistry B

Design of simultaneous antimicrobial and anticoagulant surfaces based on nanoparticles and polysaccharides†

Doris Breitwieser,a   Stefan Spirk,*bc   Hubert Fasl,a   Heike M. A. Ehmann,ab   Angela Chemelli,a   Victoria E. Reichel,a   Christian Gspan,d   Karin Stana-Kleinschekb  and  Volker Ribitsch*a  

* Corresponding authors

a Institute of Chemistry, Karl-Franzens-University Graz, Austria
E-mail: volker.ribitsch@uni-graz.at

b Institute for Engineering Materials and Design, Laboratory for Characterization and Processing of Polymers, University of Maribor, Slovenia

c Institute for Chemistry and Technology of Materials, University of Technology Graz, Austria
E-mail: stefan_spirk@yahoo.de

d Institute for Electron Microscopy and Fine Structure Research, Centre for Electron Microscopy Graz, Austria

Abstract

The rational design of silver nanoparticles encapsulated in an anticoagulant, hemocompatible polysaccharide, 6-O-chitosan sulfate, is presented. Three different approaches are described for the immobilization of these core shell particles on cellulosic surfaces. The mass of the immobilized particles is quantified using a quartz crystal microbalance with dissipation (QCM-D). The antimicrobial activity of the surfaces towards E. coli MG 1655 [R1-16] is investigated by live/dead assays using fluorescence staining. All surfaces treated with the designed nanoparticles exhibit excellent antimicrobial activity towards E. coli MG 1655 [R1-16]. Anticoagulant properties of blood plasma on the nanoparticle treated surfaces have been determined using QCM-D. In comparison with the unmodified substrates, the total coagulation time as well as the thrombin formation time and fibrin clotting time of surfaces modified with nanoparticles are significantly increased.

Graphical abstract: Design of simultaneous antimicrobial and anticoagulant surfaces based on nanoparticles and polysaccharides

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Article information

DOI
https://doi.org/10.1039/C3TB00272A
Article type
Paper
Submitted
18 Oct 2012
Accepted
12 Feb 2013
First published
12 Feb 2013

J. Mater. Chem. B, 2013,1, 2022-2030

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Design of simultaneous antimicrobial and anticoagulant surfaces based on nanoparticles and polysaccharides

D. Breitwieser, S. Spirk, H. Fasl, H. M. A. Ehmann, A. Chemelli, V. E. Reichel, C. Gspan, K. Stana-Kleinschek and V. Ribitsch, J. Mater. Chem. B, 2013, 1, 2022 DOI: 10.1039/C3TB00272A

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