Issue 92, 2014

Polymethylmethacrylate doped with porphyrin and silver nanoparticles as light-activated antimicrobial material

Abstract

Light-activated antimicrobial materials based on polymethylmethacrylate doped with porphyrin and silver nanoparticles were prepared and studied. The inspiration for the material design originates from photodynamic therapy where light is used to destroy pathogen microbes. Antimicrobial response of the materials is controlled by blue light illumination. Porphyrin molecules serve as light absorbers with dual antimicrobial response under illumination they produce reactive oxygen and affect the kinetics of silver release from the polymer. Silver is responsive for the antimicrobial effect, for the protection of porphyrin against photobleaching and for the conservation of energy through suppression of porphyrin luminescence. Triggerable and enhanced antimicrobial response of the material is activated through several possible mechanisms, including local heating of the polymer matrix, transfer of the excited state from porphyrin to silver and the synergetic effect of reactive oxygen and silver. In a passive state the material exhibits weak antimicrobial response against Gram-negative bacteria. In an active state, however, it is fatal for both Gram negative and Gram positive bacteria.

Graphical abstract: Polymethylmethacrylate doped with porphyrin and silver nanoparticles as light-activated antimicrobial material

Article information

Article type
Paper
Submitted
08 Aug 2014
Accepted
02 Oct 2014
First published
02 Oct 2014

RSC Adv., 2014,4, 50624-50630

Author version available

Polymethylmethacrylate doped with porphyrin and silver nanoparticles as light-activated antimicrobial material

O. Lyutakov, O. Hejna, A. Solovyev, Y. Kalachyova and V. Svorcik, RSC Adv., 2014, 4, 50624 DOI: 10.1039/C4RA08385G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements