Issue 44, 2017, Issue in Progress
From the journal:

RSC Advances

Overcoming the blood–brain barrier for glioma-targeted therapy based on an interleukin-6 receptor-mediated micelle system†

Wei Shi,b   Xuexue Cui,a   Jinlong Shi,b   Jian Chenb  and  Yi Wang ORCID logo *ac  

* Corresponding authors

a Center for Advanced Low-dimension Materials, Donghua University, Shanghai 201620, China
E-mail: ywang@dhu.edu.cn

b Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong 226001, China

c Center of Analysis and Measurement, Fudan University, Shanghai 200433, China

Abstract

Treatments of cancer in the central nervous system (CNS), such as glioma, require nano-drugs to efficiently cross the blood–brain barrier (BBB) and highly accumulate within tumor regions. In this work, a new interleukin-6 receptor-mediated micelle system, where a short peptide I6P8 was conjugated to biodegradable poly(ethylene glycol)–poly(lactic-co-glycolic acid) (PEG–PLGA), was prepared for cascade-targeting drug delivery to glioma. In vitro results showed that the I6P8-conjugated doxorubicin (DOX)-loaded micelle (I6P8-D-M) could significantly transport across the BBB and subsequently target the glioma cells, which was superior to results of scrambled peptide-modified counterparts. While in vivo results confirmed that this multifunctional I6P8-D-M could introduce the highest glioma apoptosis and longest survival of glioma-bearing mice as compared to other groups. These findings suggest that the I6P8-D-M micelle system is a promising cascade-targeting therapeutic agent, which can overcome the BBB for glioma-targeted therapy.

Graphical abstract: Overcoming the blood–brain barrier for glioma-targeted therapy based on an interleukin-6 receptor-mediated micelle system

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Article information

DOI
https://doi.org/10.1039/C7RA03208K
Article type
Paper
Submitted
18 Mar 2017
Accepted
13 May 2017
First published
23 May 2017
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2017,7, 27162-27169

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Overcoming the blood–brain barrier for glioma-targeted therapy based on an interleukin-6 receptor-mediated micelle system

W. Shi, X. Cui, J. Shi, J. Chen and Y. Wang, RSC Adv., 2017, 7, 27162 DOI: 10.1039/C7RA03208K

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