Antiviral Activities against HSV-1, HCMV, and HIV-1 of Rhamnan Sulfate from Monostroma latissimum

Jung-Bum Lee; Kyoko Hayashi; Toshimitsu Hayashi; Ushio Sankawa; Masaakira Maeda

doi:10.1055/s-2006-960804

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Planta Med 1999; 65(5): 439-441
DOI: 10.1055/s-2006-960804

Letter

Antiviral Activities against HSV-1, HCMV, and HIV-1 of Rhamnan Sulfate from Monostroma latissimum

Jung-Bum Lee¹ , Kyoko Hayashi² , Toshimitsu Hayashi¹ , Ushio Sankawa¹ , Masaakira Maeda³

¹Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Toyama, Japan
²School of Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
³Department of Biochemistry, Saitama University, Urawa, Japan

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Publication History

1998

1999

Publication Date:
04 January 2007 (online)

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Abstract

Rhamnan sulfate (RS), a natural sulfated polysaccharide isolated from Monostromo latissimum, showed potent inhibitory effects on the virus replication of herpes simplex virus type 1 (HSV-1), human cytomegalovirus (HCMV), and human immunodeficiency virus type 1 (HIV-1) in vitro. The antiviral action of RS was not only due to the inhibition of virus adsorption, but also might involve the later steps of viral replication in host cells on the basis of the results of time-of-addition experiments. Furthermore, RS and 3′-azido-3′-deoxythymidine (AZT) were synergistic in their anti-HIV-1 activities. These data indicate that RS is a potent antiviral substance against HSV-1, HCMV, and HIV-1.

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