Abstract
In Part I of this series (Snyder et al., 1999a), the Chemical Scoring and Ranking Assessment Model (SCRAM) was introduced. This system produces scores for chemicals based on their bioaccumulation potential, environmental persistence, and toxicity. In Part II, scoring of the potential for a chemical to persist in the environment and bioaccumulate was described (Snyder et al., 1999b). In Part III, scoring of chemical toxicity is discussed, including definitions and descriptions of effects that are scored, specific scoring instructions, the basis for the criteria and scores, and specific conditions or concerns regarding the types of data used for scoring. A score for each chemical screened is determined from available test data from acute or subchronic and chronic toxicity tests conducted on aquatic and terrestrial organisms. Subchronic and chronic human health effects, including carcinogenicity, are also considered. Part IV includes an evaluation of the performance of the scoring and ranking system (Snyder et al., 1999c).
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ASTM (1992a): Standard guide for conducting acute toxicity tests with fishes, macroinvertebrates, and amphibians. Designation E 729-88a. Pages 403–422. In: 1992 Annual book of ASTM standards. Section 11. Water and environmental technology. Volume 11.04. Pesticides; resource recovery; hazardous substances and oil spill responses; waste management; biological effects. Publication code # 01-110492-48. American Society for Testing and Materials, Philadelphia, PA
ASTM (1992b): Standard guide for conducting early life-stage toxicity tests with fishes. Designation E 1241-92. Pages 886–913. In: 1992 Annual book of ASTM standards. Section 11. Water and environmental technology. Volume 11.04. Pesticides; resource recovery; hazardous substances and oil spill responses; waste management; biological effects. Publication code #01-110492-48. American Society for Testing and Materials, Philadelphia, PA
ASTM (1992c): Standard guide for conducting renewal life-cycle toxicity tests with Daphnia magna. Designation E1193-87. Pages 866–882. In: 1992 Annual book of ASTM standards. Section 11. Water and environmental technology. Volume 11.04. Pesticides; resource recovery; hazardous substances and oil spill responses; waste management; biological effects. Publication code # 01-110492-48. American Society for Testing and Materials, Philadelphia, PA
Foran, J.A.; Glenn, B.S. (1993): Criteria to identify chemical candidates for sunsetting in the Great Lakes Basin. The George Washington University, Environmental Health and Policy Program, Department of Health Care Sciences, Washington, DC
Hartung, R.; Durkin, P.R. (1986): Ranking the severity of toxic effects: Potential applications to risk assessment. Comments Toxicol. 1, 49–63
MDNR (1987): Michigan Critical Materials Register criteria and support document. Michigan Department of Natural Resources, Surface Water Quality Division, Lansing, MI
OMOE (1990): Ontario MOE scoring system. Ontario Ministry of the Environment, Hazardous Contaminants Coordination Branch. Toronto, Ontario
National Toxicology Program (1984): Report of the Ad Hoc Panel, on Chemical Carcinogenesis Testing and Evaluation of National Toxicology Program, Board of Scientific Counselors. U.S. Government Printing Office, Washington, DC, 1984-421-132:4726
O’Bryan, T.R.; Ross, R.H. (1988): Oak Ridge National Laboratory. 1988. Chemical scoring system for hazard and exposure identification. J. Toxicol. Environ. Health 1, 119–134
OECD (1981): Guidelines for testing of chemicals. Organization for Economic Cooperation and Development. Paris, France
Office of Science and Technology Policy (1985): Chemical carcinogens: Review of the science and its associated principles. Federal Register 50 (March 14, 1985), 10372–10442
Rand, G.M. (Ed.) (1995): Fundamentals of aquatic toxicology: Effects, environmental fate, and risk assessment. 2nd edition. Taylor & Francis, Washington, DC, pp. 1125
Snyder, E.M.; Snyder, S.A.; Giesy, J.P.; Blonde, S.A.; Hurlburt, G.K.; Summer, C.L.; Mitchell, R.R.; Bush, D.M. (1999a): SCRAM: A scoring and ranking system for persistent, bioaccumulative, and toxic substances for the North American Great Lakes. Part I. Structure of the scoring and ranking system. ESPR — Environ. Sci. & Pollut. Res. Online Publication (Online First): October 29th, 1999. Print Publication: ESPR 7 (1) 2000
Snyder, E.M.; Snyder, S.A.; Giesy, J.P.; Blonde, S.A.; Hurlburt, G.K.; Summer, C.L.; Mitchell, R.R.; Bush, D.M. (1999b): SCRAM: A scoring and ranking system for persistent, bioaccumulative, and toxic substances for the North American Great Lakes. Part II. Bioaccumulation potential and persistence. Acute and subchronic or chronic toxicity. ESPR — Environ. Sci. & Pollut. Res. Online Publication (Online First): October 29th, 1999. Print Publication: ESPR 7 (3) 2000
Snyder, E.M.; Snyder, S.A.; Giesy, J.P.; Blonde, S.A.; Hurlburt, G.K.; Summer, C.L.; Mitchell, R.R.; Bush, D.M. (1999c): SCRAM: A scoring and ranking system for persistent, bioaccumulative, and toxic substances for the North American Great Lakes. Part IV. Results from representative chemicals, sensitivity analysis, and discriminatory power. ESPR — Environ. Sci. & Pollut. Res. Online Publication (Online First): October 29th, 1999. Print Publication: ESPR 7 (4) 2000
Soto, A.M.; Justica, H.; Wray, J.W.; Sonnenschein, C. (1991): p-Nonylphenol: an estrogenic xenobiotic released from “modified” polystyrene. Env. Health Perspect. 92, 167–173
U.S. EPA (1985): Toxic Substances Control Act test guidelines; final rules. Federal Register 50(188) (September 27, 1985), 39421–39425
U.S. EPA (1987): Reportable Quantity adjustments; proposed rule. Federal Register 52(50) (March 16,1987), 8140–8186
U.S. EPA (1989a): Reportable Quantity adjustments; final rule. Federal Register 54(155) (August 14,1989), 33418–33484
U.S. EPA (1989b): Technical background document to support rule making pursuant to CERCLA Section 102. Volume 3. United States Environmental Protection Agency, Office of Solid Waste and Emergency Response. Washington, DC
U.S. EPA (1991): Pesticide assessment guidelines, subdivision F. Hazard evaluation: Human and domestic animals. United States Environmental Protection Agency, Office of Pollution Prevention and Toxics. Washington, DC
U.S. EPA (1993): Chemical use clusters scoring methodology. United States Environmental Protection Agency, Office of Pollution Prevention and Toxics, Chemical Engineering Branch, Washington, DC. pp. 57
U.S. EPA (1995a): Proposed guidelines for neurotoxicity risk assessment; public notice. Federal Register 60(192) (October 4, 1995), 52032–52056
U.S. EPA (1995b): Water quality guidance for the Great Lakes system; final rules. Federal Register 60(56) (March 23, 1995), 15366–15425
U.S. EPA (1996): Proposed guidelines for carcinogen risk assessment. United States Environmental Protection Agency. Federal Register 51(185), September
Weil, C.S.; McCollister, D.D. (1963): Relationship between short and long term feeding studies in designing an effective toxicity test. Agr. Food Chem. 11(6), 486–491
White, R.; Jobling, S.; Hoare, S.A.; Sumpter, J.P.; Parker, M.G. (1994): Environmentally persistent alkylphenolic compounds are oestrogenic. Endo. 135, 175–182
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The scoring and ranking system in the form of a Lotus 12397 spreadsheet and a description of its use are available on the Internet at htto://www.epa. gov/toxteam/pbtrept/
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Snyder, E.M., Snyder, S.A., Giesy, J.P. et al. SCRAM: A scoring and ranking system for persistent, bioaccumulative, and toxic substances for the North American Great Lakes. Environ. Sci. & Pollut. Res. 7, 176–184 (2000). https://doi.org/10.1065/espr199910.011
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DOI: https://doi.org/10.1065/espr199910.011