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Three-dimensional real-time in vivo magnetic particle imaging

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Published 10 February 2009 • 2009 Institute of Physics and Engineering in Medicine
, , Citation J Weizenecker et al 2009 Phys. Med. Biol. 54 L1 DOI 10.1088/0031-9155/54/5/L01

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1 Philips Research Europe – Hamburg, Sector Medical Imaging Systems, Röntgenstrasse 24-26, 22335 Hamburg, Germany

Dates

  1. Received 28 October 2008
  2. Published

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0031-9155/54/5/L1

Abstract

Magnetic particle imaging (MPI) is a new tomographic imaging method potentially capable of rapid 3D dynamic imaging of magnetic tracer materials. Until now, only dynamic 2D phantom experiments with high tracer concentrations have been demonstrated. In this letter, first in vivo 3D real-time MPI scans are presented revealing details of a beating mouse heart using a clinically approved concentration of a commercially available MRI contrast agent. A temporal resolution of 21.5 ms is achieved at a 3D field of view of 20.4 × 12 × 16.8 mm3 with a spatial resolution sufficient to resolve all heart chambers. With these abilities, MPI has taken a huge step toward medical application.

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Video 1. Fusion of the MPI and MRI images as a function of time after bolus injection of Resovist (dosage 45 µmol(Fe)/kg). A sagittal view at slice number 20 is shown. Entering of the bolus into the field of view via the vena cava as well as the right atrium can be observed. (510 KB MPEG)

Video 2. Fusion of the MPI and MRI images as a function of time after bolus injection of Resovist (dosage 45 µmol(Fe)/kg). A transversal view at slice number 167 is shown. Entering of the bolus into the field of view via the vena cava can be observed. (1.89 MB MPEG)

Video 3. Fusion of the MPI and MRI images as a function of time after bolus injection of Resovist (dosage 45 µmol(Fe)/kg). A coronal view at slice number 48 is shown. Entering of the bolus into the field of view via the vena cava can be observed. (698 KB MPEG)

Video 4. Fusion of the MPI and MRI images as a function of time after bolus injection of Resovist (dosage 45 µmol(Fe)/kg). A transversal view at slice number 134 is shown. The filling of the right atrium can be observed. (232 KB MPEG)

Video 5. Fusion of the MPI and MRI images as a function of time after bolus injection of Resovist (dosage 45 µmol(Fe)/kg). A coronal view at slice number 31 is shown. The filling of the right atrium and the left ventricle can be observed. (636 KB MPEG)

Video 6. Fusion of the MPI and MRI images as a function of time after bolus injection of Resovist (dosage 45 µmol(Fe)/kg). A sagittal view at slice number 29 is shown. The filling of the right and left ventricle can be observed. (576 KB MPEG)

Video 7. Fusion of the MPI and MRI images as a function of time after bolus injection of Resovist (dosage 45 µmol(Fe)/kg). A transversal view at slice number 141 is shown. The filling of the right ventricle, the pulmonary arteries and the left ventricle can be observed. (224 KB MPEG)

Video 8. Fusion of the MPI and MRI images as a function of time after bolus injection of Resovist (dosage 45 µmol(Fe)/kg). A sagittal view at slice number 19 is shown. The filling of vena cava and vessel tree can be observed. (508 KB MPEG)

Video 9. Fusion of the MPI and MRI images as a function of time after bolus injection of Resovist (dosage 45 µmol(Fe)/kg). A coronal view at slice number 45 is shown. The filling of the pulmonary vessel tree can be observed. (684 KB MPEG)

Video 10. Sagittal MPI image slice through the mouse heart as a function of time after bolus injection of Resovist (dosage 10 µmol(Fe)/kg). In the movie, the right atrium and ventricle as well as the vena cava can be observed. The first frame of the movie corresponds to a time of 5.375 seconds after start of the measurement. (1.37 MB MPEG)

Video 11. Transversal MPI image slice through the mouse heart as a function of time after bolus injection of Resovist (dosage µ10 mol(Fe)/kg). In the movie, the right atrium and both ventricles as well as the pulmonary arteries can be observed. The first frame of the movie corresponds to a time of 5.375 seconds after start of the measurement. (1.90 MB MPEG)

Video 12. Coronal MPI image slice through the mouse heart as a function of time after bolus injection of Resovist (dosage 10 µmol(Fe)/kg). In the movie, both arteries and ventricles can be observed. The first frame of the movie corresponds to a time of 5.375 seconds after start of the measurement. (1.89 MB MPEG)

Supplementary figure 1 (106 KB PDF).

10.1088/0031-9155/54/5/L01