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Axonal guidance on patterned free-standing nanowire surfaces

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Published 15 July 2008 IOP Publishing Ltd
, , Citation Christelle Prinz et al 2008 Nanotechnology 19 345101 DOI 10.1088/0957-4484/19/34/345101

0957-4484/19/34/345101

Abstract

We demonstrate high-fidelity guidance of axons using rows of nanowires. The axons are prevented from crossing the rows, making it possible to guide and sort a large number of axons as opposed to when chemical patterns are used. Focal adhesion forms at the nanowires establishing a possible site of information transfer between the surface and the cells. Rows of gallium phosphide (GaP) nanowires were epitaxially grown on GaP(111) substrates in patterns defined by electron beam lithography.

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10.1088/0957-4484/19/34/345101