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Volume 154, Issue 11

RNAIII divergently regulates glucose-induced biofilm formation in clinical isolates of Free

Abstract

is an important nosocomial and community-acquired pathogen. Hospital infections are frequently complicated by the ability of bacteria to form biofilms on different surfaces. The development of bacterial films on medical indwelling devices, such as prostheses, often requires surgical procedures to remove the contaminated implant. Indeed, biofilm formation on central endovenous catheters is a major cause of primary bacteraemia in hospitals. The modulation of virulence factors in is orchestrated by a number of global regulators including RNAIII. To improve our understanding of the role of the quorum-sensing system in biofilm formation by , we constructed a number of -null mutants, derived from contemporary clinical isolates. Analysis of these mutants indicates that has a significant impact on biofilm development for most of the isolates tested. Our data show that RNAIII can control both biofilm formation and accumulation. The effect included both up- and downregulation of biofilms, even for isolates within the same lineage, corroborating the hypothesis that the mechanisms involved in biofilms are complex and probably multifactorial.

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  • Accepted:
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  • Published Online:
Keyword(s): AIP, Agr autoinducing peptide , BEC, Brazilian epidemic clone , BU, biofilm unit , CLSM, confocal laser scanning microscopy , CS, conditioned supernatant , MRSA, meticillin-resistant S. aureus , MSSA, meticillin-susceptible S. aureus and WT, wild-type
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2008-11-01
2024-04-19
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agr RNAIII divergently regulates glucose-induced biofilm formation in clinical isolates of Staphylococcus aureus
Microbiology 154, 3480 (2008); https://doi.org/10.1099/mic.0.2007/016014-0
/content/journal/micro/10.1099/mic.0.2007/016014-0
/content/journal/micro/10.1099/mic.0.2007/016014-0
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