Shape transformations of two-compoent vesicles in which the spontaneous curvature depends on the local compositions in the two monolayers are investigated theoretically. Even if the two components do not exhibit lateral phase separation in spherical vesicles, temperature-induced shape transformations cause lateral phase segregation. Vesiculation of smaller buds is favored in the two-component system. In two-component vesicles with intermonolayer phase separation, thermal budding is dominated by the different thermal expansion coefficients of the two monolayers.

• Received 2 November 1992

DOI:https://doi.org/10.1103/PhysRevLett.70.1335