Spatiotemporal Control of Wave Instabilities in Cardiac Tissue

Wouter-Jan Rappel, Flavio Fenton, and Alain Karma
Phys. Rev. Lett. 83, 456 – Published 12 July 1999
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Abstract

Electrical waves circulating around an obstacle in cardiac tissue are subject to a generic oscillatory instability. In a one-dimensional ring geometry this instability can produce both quasiperiodic and spatiotemporally chaotic oscillations while in a two-dimensional sheet of cardiac tissue it can lead to spiral wave breakup. We present a control scheme to prevent this instability in these two geometries which is based on applying a feedback current at a discrete set of control points during the repolarizing phase of the action potential. The feasibility of this scheme is demonstrated via simulations of a two-variable model of excitable media with restitution and of the Beeler-Reuter model of ventricular action potential.

  • Received 30 November 1998

DOI:https://doi.org/10.1103/PhysRevLett.83.456

©1999 American Physical Society

Authors & Affiliations

Wouter-Jan Rappel

  • Department of Physics, University of California, San Diego, La Jolla, California 92093

Flavio Fenton and Alain Karma

  • Department of Physics and Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, Massachusetts 02115

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Vol. 83, Iss. 2 — 12 July 1999

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