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Preparation of new cefazolin-containing films based on chitosan and carboxyarabinogalactan

  • Macromolecular Compounds and Polymeric Materials
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Abstract

Preparation of a polyelectrolyte complex of chitosan with the oxidized form of Siberian larch arabinogalactan at the component ratio from 0.05: 1 to 1: 1 was studied by spectrometry and laser scattering. Water-insoluble films based on this complex were prepared. These films were used as a matrix for drug immobilization. The possibility of controlling the rate and degree of the drug release from the film by variation of the polysaccharide ratio, modification of the polymer film with a sodium dodecyl sulfate solution, or heat treatment was demonstrated with cefazolin antibiotic as example. The films obtained exhibit high bactericidal activity.

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Authors and Affiliations

  1. Ufa Institute of Chemistry, Russian Academy of Sciences, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054, Russia

    L. A. Badykova, R. Kh. Mudarisova & M. S. Gurina

  2. Akmulla Bashkir State Pedagogical University, ul. Oktyabr’skoi Revolutsii 3, Ufa, Bashkortostan, 450076, Russia

    I. M. Borisov

Authors
  1. L. A. Badykova
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  2. R. Kh. Mudarisova
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  3. I. M. Borisov
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  4. M. S. Gurina
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Corresponding author

Correspondence to L. A. Badykova.

Additional information

Original Russian Text © L.A. Badykova, R.Kh. Mudarisova, I.M. Borisov, M.S. Gurina, 2016, published in Zhurnal Prikladnoi Khimii, 2016, Vol. 89, No. 7, pp. 935−941.

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Badykova, L.A., Mudarisova, R.K., Borisov, I.M. et al. Preparation of new cefazolin-containing films based on chitosan and carboxyarabinogalactan. Russ J Appl Chem 89, 1126–1131 (2016). https://doi.org/10.1134/S1070427216070120

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  • DOI: https://doi.org/10.1134/S1070427216070120

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