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From Carrel to Hayflick and back, or what we got from the 100-year cytogerontological studies

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Abstract

The history of gerontological experiments on cell cultures is reviewed. Cytogerontological studies and aging theories by Weismann, Carrel, Hayflick, and the author are compared. It is emphasized that the basic notion of aging mechanisms was deeply revised several times within the 20th century. It is concluded that at present the aging of multicellular organisms cannot be satisfactorily explained with the help of cytogerontological studie’s data. Experiments on cell cultures need to be combined with fundamental gerontological studies, including survival curve analysis for humans or experimental animals.

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References

  1. L. Hayflick, Mech. Ageing Dev. 9(5–6), 393 (1979).

    Article  Google Scholar 

  2. A. N. Khokhlov, Proliferation and Ageing (VINITI, Moscow, 1988) [in Russian].

    Google Scholar 

  3. S. N. Austad, Why We Age: What Science Is Discovering about the Body’s Journey Through Life (John Wiley & Sons, Inc., Chichester, 1999).

    Google Scholar 

  4. C. E. Finch, Longevity, Senescence, and the Genome (University of Chicago Press, Chicago-London, 1990).

    Google Scholar 

  5. R. Holliday, Aging: the Paradox of Life. Why We Age (Springer, Dordrecht, 2007).

    Google Scholar 

  6. A. Comfort, Ageing: the Biology of Senescence (Holt, Rinehart and Winston, New York, 1964).

    Google Scholar 

  7. L. Hayflick, How and Why We Age, (Ballantine Books, New York, 1994).

    Google Scholar 

  8. A. Weismann, Die Kontinuitat des Keimplasmas als Grundlage einer Theorie der Vererbung (G. Fischer Verlag, Jena, 1885).

    Google Scholar 

  9. A. Weismann, Das Keimplasma. Eine Theorie der Vererbung (G. Fischer Verlag, Jena, 1892).

    Google Scholar 

  10. T. B. L. Kirkwood and T. Grener, Hum. Genet. 60, 101 (1982).

    Article  Google Scholar 

  11. P. K. Stanford, Hist. Philos. Life Sci. 27, 163 (2005).

    Google Scholar 

  12. R. G. Winther, J. Hist. Biol. 34, 517 (2001).

    Article  Google Scholar 

  13. A. Carrel, J. Exp. Med. 17, 14 (1912).

    Article  Google Scholar 

  14. A. Carrel, J. Exp. Med. 18, 287 (1913).

    Article  Google Scholar 

  15. H. E. Swim and R. F. Parker, Am. J. Hyg. 66, 235 (1957).

    Google Scholar 

  16. L. Hayflick, Exp. Cell Res. 37, 614 (1965).

    Article  Google Scholar 

  17. L. Hayflick, Mech. Ageing Dev. 9, 393 (1979).

    Article  Google Scholar 

  18. S. I. S. Rattan, Biogerontology 1, 79 (2000).

    Article  Google Scholar 

  19. A. M. Olovnikov, Dokl. AN SSSR 201, 1496 (1971).

    Google Scholar 

  20. V. J. Cristofalo, R. G. Allen, R. J. Pignolo, et al., Proc. Natl. Acad. Sci. 95, 10614 (1998).

    Article  ADS  Google Scholar 

  21. A. G. Bodnar, M. Ouelette, M. Frolkis, et al., Science 279, 349 (1998).

    Article  ADS  Google Scholar 

  22. A. N. Khokhlov, Tsitologiya 44, 1143 (2002).

    Google Scholar 

  23. A. N. Khokhlov, Ontogenez 34, 382 (2003).

    Google Scholar 

  24. A. N. Khokhlov, Probl. stareniya i dolgoletiya 17(4), 451 (2008).

    Google Scholar 

  25. A. N. Khokhlov, Probl. stareniya i dolgoletiya 18(1), 32 (2009).

    Google Scholar 

  26. A. N. Khokhlov, Z. Gerontol. Geriat. 32(Suppl. 2), 191 (1999).

    Google Scholar 

  27. A. N. Khokhlov, in Biomarkers of aging: expression and regulation, Ed. by F. Licastro and C. M. Caldarera (CLUEB, Bologna, 1992), pp. 209–216.

    Google Scholar 

  28. E. Yu. Chirkova, M. E. Golovinya, T. L. Nadzharyan, and A. N. Khokhlov, Dokl. AN SSSR 278, 1474 (1984).

    Google Scholar 

  29. A. N. Khokhlov, Ann. N.Y. Acad. Sci. 663, 475 (1992).

    Article  ADS  Google Scholar 

  30. A. N. Khokhlov, Ann. N.Y. Acad. Sci. 854, 519 (1998).

    Article  MathSciNet  ADS  Google Scholar 

  31. A. N. Khokhlov, E. Yu. Chirkova, and T. L. Nadzharyan, Tsitologiya 26, 965 (1984).

    Google Scholar 

  32. A. N. Khokhlov, E. Yu. Chirkova, and A. I. Gorin, Byull. eksperim. biol. med. 101(4) 416 (1986).

    Google Scholar 

  33. A. N. Khokhlov, E. Yu. Chirkova, and A. N. Chebotarev, Tsitologiya i genetika 21(3) 186 (1987).

    Google Scholar 

  34. A. N. Khokhlov, M. D. Kirnos, and B. F. Vanyushin, Izv. AN SSSR. Ser. biol., No. 3, 476 (1988).

  35. S. I. Shram, G. A. Shilovskii, and A. N. Khokhlov, Byull. eksperim. biol. med. 141(5), 567 (2006).

    Article  Google Scholar 

  36. D. S. Esipov, T. A. Gorbacheva, G. A. Khairullina, et al., Usp. Gerontol. 21(3), 485 (2008).

    Google Scholar 

  37. G. P. Bidder, Brit. Med. J., 2, 583 (1932).

    Article  Google Scholar 

  38. C. S. Minot, The Problem of Age, Growth, and Death; a Study of Cytomorphosis, Based on the Lectures at the Lowell Institute, March 1907 (G. P. Patnam’s Sons, New York-London, 1908).

    Google Scholar 

  39. I. I. Schmalhausen, The Problem of Death and Immortality (Moscow-Leningrad, 1926).

  40. P. Brian, in The Origin and Development of Germinal Cells in the Development of Vertebrates and Some Invertebrate Taxa (Meditsina, Leningrad, 1968), pp. 17–74 [in Russian].

    Google Scholar 

  41. A. N. Khokhlov, L. Yu. Prokhorov, A. S. Ivanov, and A. I. Archakov, FEBS Lett. 290, 171 (1991).

    Article  Google Scholar 

  42. A. B. Maier, I. L. Maier, D. von Heems, and R. G. J. Westendorp, J. Gerontol. Biol. Sci. 63A, 655 (2008).

    Google Scholar 

  43. A. D. N. J. de Grey, The Mitochondrial Free Radical Theory of Aging (Molecular Biology Intelligence Unit 9) (R.G. Landes Company, Austin, TX, 1999).

    Google Scholar 

  44. V. D. Longo, J. Mitteldorf, and V. P. Skulachev, Nat. Rev. Genet. 6, 866 (2005).

    Article  Google Scholar 

  45. D. E. Bredesen, Aging Cell 3, 255 (2004).

    Article  Google Scholar 

  46. K. Lewis, Mech. Ageing Dev. 109, 43 (1999).

    Article  Google Scholar 

  47. A.-S. Goddo, Eur. J. Plast. Surg. 14, 261 (1991).

    Google Scholar 

  48. T. B. L. Kirkwood, Mech. Ageing Dev. 123, 737 (2002).

    Article  Google Scholar 

  49. S. N. Austad, Aging Cell 3, 253 (2004).

    Article  Google Scholar 

  50. D. E. Bredesen, Aging Cell 3, 261 (2004).

    Article  Google Scholar 

  51. S. I. S. Rattan, FASEB J. 9, 284 (1995).

    Google Scholar 

  52. J. R. Vanfleteren and B. P. Braeckman, Neurobiol Aging 20, 487 (1999).

    Article  Google Scholar 

  53. G. McColl, N. L. Jenkins, D. W. Walker, and G. J. Lithgow, Ann. N.Y. Acad. Sci 908, 319 (2000).

    Article  ADS  Google Scholar 

  54. D. W. Walker, G. McColl, N. L. Jenkins, et al., Nature 405, 296 (2000).

    Article  ADS  Google Scholar 

  55. N. L. Jenkins, G. McColl, and G. J. Lithgow, Proc. Biol. Sci. 271, 2523 (2004).

    Article  Google Scholar 

  56. A. N. Khokhlov, Ros. Khim. Zhurn. 53(3) 111 (2009).

    Google Scholar 

  57. Zh. A. Medvedev, Mech. Ageing Dev. 17, 331 (1981).

    Article  Google Scholar 

  58. V. P. Skulachev, Quart. Rev. Biophys. 29, 169 (1996).

    Article  Google Scholar 

  59. V. I. Padalko, Biokhimiya 70(9) 986 (2005).

    Google Scholar 

  60. A. F. Karmushakov, A. D. Kulikovskii, A. A. Klebanov, and A. N. Khokhlov, in Biologic Mechanisms of Aging, 8th International Symposium, May 21–24, 2008. Abstracts (Kharkov, 2008), p. 35 [in Russian].

  61. A. N. Khokhlov, M. E. Golovina, E. Yu. Chirkova, and T. L. Nadzharyan, Tsitologiya 29(3) 353 (1987).

    Google Scholar 

  62. A. M. Olovnikov, Ann. N.Y. Acad. Sci. 1057, 112 (2005).

    Article  ADS  Google Scholar 

  63. A. M. Olovnikov, J. Alzheimer’s Dis. 11, 241 (2007).

    Google Scholar 

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Authors and Affiliations

  1. Evolutionary Cytogerontology Sector, School of Biology, Moscow State University, Moscow, Russia

    A. N. Khokhlov

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Correspondence to A. N. Khokhlov.

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Original Russian Text © A.N. Khokhlov, 2010, published in Radiatsionnaya Biologiya. Radioekologiya, 2010, Vol. 50, No. 3, pp. 304–311.

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Khokhlov, A.N. From Carrel to Hayflick and back, or what we got from the 100-year cytogerontological studies. BIOPHYSICS 55, 859–864 (2010). https://doi.org/10.1134/S0006350910050313

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