Abstract
Three-dimensional spiral waves of electrical excitation in the myocardium are sources of dangerous cardiac arrhythmias. In this work, the dynamics of spiral waves of electrical excitation were studied in a symmetric anatomical model of the human heart left ventricle and a realistic ionic cell model of the human ventricular myocardium. Three factors that affect the drift waves in the heart were compared for the first time: the geometry of the heart wall, myocardial anisotropy, and wave chirality. Cardiac anisotropy was identified as a main factor in determining the drift of spiral waves. In the isotropic case, the dynamics were determined by the wall thickness, but did not depend on the wave chirality. In the anisotropic case, chirality was found to play a crucial role.
Similar content being viewed by others
Abbreviations
- LV:
-
left ventricle
References
A. T. Winfree and S. H. Strogatz, Nature 311, 5987 (1984).
J. M. Davidenko, et al., Nature 355, 6358 (1992).
R. Gray, et al., Circulation 91 (1995).
A. V. Panfilov and B. N. Vasiev, Physica D 49 (1991).
A. N. Rudenko and A. V. Panfilov, Studia Biophysica 98 (1983).
H. Dierckx, E. Brisard, H. Verschelde, and A. V. Panfilov, Phys. Rev. E 88, 1 (2013).
A. V. Panfilov and A. N. Rudenko, Physica D 28, 215 (1987).
S. F. Pravdin, et al., BioMed. Engin. Online 12, 54 (2013).
K. H. ten Tusscher, D. Noble, P. J. Noble, and A. V. Panfilov, Am. J. Physiol. Heart Circ. Physiol. 286, H1573 (2004).
K. H. ten Tusscher and A. V. Panfilov, Am. J. Physiol. Heart Circ. Physiol. 291, H1088 (2006).
K. H. ten Tusscher, R. Hren, and A. V. Panfilov, Circ. Res. 100, 12 (2007).
B. J. Caldwell, et al., Circ. Arrhythm. Electrophysiol. 2 (4), 433 (2009).
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © S.F. Pravdin, H. Dierckx, A.V. Panfilov, 2017, published in Biofizika, 2017, Vol. 62, No. 2, pp. 391–394.
Rights and permissions
About this article
Cite this article
Pravdin, S.F., Dierckx, H. & Panfilov, A.V. Effect of the form and anisotropy of the left ventricle on the drift of spiral waves. BIOPHYSICS 62, 309–311 (2017). https://doi.org/10.1134/S0006350917020208
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0006350917020208