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Preparation of Bioactive Mesoporous Calcium Phosphate Granules

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Abstract

Mesoporous calcium phosphate granules ranging in mesopore size from 11 to 19 nm have been prepared using cryogenic processing (–18°C) of gels and extrusion of calcium phosphate paste. The granules based on acid calcium phosphates have a relatively small specific surface area (45 m2/g) in comparison with the neutral and basic calcium phosphates (84–155 m2/g). Preclinical in vivo trials on rats show that the presence of calcium phosphate granules in a bone defect considerably accelerates reparative osteogenesis in comparison with a control group of animals.

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Authors and Affiliations

  1. Institute of General and Inorganic Chemistry, Belarusian Academy of Sciences, ul. Surganova 9/1, Minsk, 220072, Belarus

    O. N. Musskaya, A. I. Kulak & V. K. Krut’ko

  2. Belarussian State University, Leningradskaya ul. 14, Minsk, 220030, Belarus

    Yu. A. Lesnikovich

  3. Republican Scientific and Practical Centre for Pediatric Surgery, pr. Nezavisimosti 64, Minsk, 220013, Belarus

    V. V. Kazbanov & N. S. Zhitkova

Authors
  1. O. N. Musskaya
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  2. A. I. Kulak
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  3. V. K. Krut’ko
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  4. Yu. A. Lesnikovich
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  5. V. V. Kazbanov
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  6. N. S. Zhitkova
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Corresponding author

Correspondence to O. N. Musskaya.

Additional information

Original Russian Text © O.N. Musskaya, A.I. Kulak, V.K. Krut’ko, Yu.A. Lesnikovich, V.V. Kazbanov, N.S. Zhitkova, 2018, published in Neorganicheskie Materialy, 2018, Vol. 54, No. 2, pp. 130–137.

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Musskaya, O.N., Kulak, A.I., Krut’ko, V.K. et al. Preparation of Bioactive Mesoporous Calcium Phosphate Granules. Inorg Mater 54, 117–124 (2018). https://doi.org/10.1134/S0020168518020115

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  • DOI: https://doi.org/10.1134/S0020168518020115

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