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Electron-conformational transformations in nanoscopic RyR channels governing both the heart’s contraction and beating

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Abstract

We show that a simple biophysically based electron-conformational model of RyR channel can explain and describe on equal footing the oscillatory regime of the heart’s cell release unit both in sinoatrial node (pacemaker) cells under normal physiological conditions and in ventricular myocytes under Ca2+ sarcoplasmic reticulum overload.

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Authors and Affiliations

  1. Department of Theoretical Physics, Ural State University, Yekaterinburg, 620083, Russia

    A. S. Moskvin & A. M. Ryvkin

  2. Institute of Immunology and Physiology, Ural Branch, Russian Academy of Sciences, Yekaterinburg, 620049, Russia

    A. M. Ryvkin, O. E. Solovyova & V. S. Markhasin

  3. Department of Computational Mathematics, Ural State University, Yekaterinburg, 620083, Russia

    O. E. Solovyova

Authors
  1. A. S. Moskvin
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  2. A. M. Ryvkin
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  3. O. E. Solovyova
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  4. V. S. Markhasin
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Corresponding author

Correspondence to A. S. Moskvin.

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Moskvin, A.S., Ryvkin, A.M., Solovyova, O.E. et al. Electron-conformational transformations in nanoscopic RyR channels governing both the heart’s contraction and beating. Jetp Lett. 93, 403–408 (2011). https://doi.org/10.1134/S0021364011070083

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  • DOI: https://doi.org/10.1134/S0021364011070083

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