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A voltammetric method for the quantitative determination of midecamycin compared to its simultaneous HPLC determination

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Abstract

The aim of this study was to present the quantitative determination of midecamycin at a gold electrode in 0.05 M NaHCO3 using cyclic linear sweep voltammetry. It was found that the value of the oxidative peak of pure midecamycin at 0.85 V vs. SCE at a scan rate of 50 mV s−1 is a linear function of the concentration in the range 0.1693–0.3289 mg cm−3. The value of its reductive peak at 0.3 V vs. SCE is a linear function of the concentration in the range 0.11396–0.3802 mg cm−3. HPLC analysis of the bulk of electrolyte confirmed the data obtained by analysis of the current peak values concerning the correlation with each investigated concentration of midecamycin. By MS spectrometry no degradation products were found in electrolyte during its quantitative determination.

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Author information

Authors and Affiliations

  1. Medicines and Medical Devices Agency of Serbia, Vojvode Stepe 458, Belgrade, Serbia

    K. M. Drljević-Djurić

  2. ICTM—Institute of Electrochemistry, University of Belgrade, Njegoševa 12, Belgrade, Serbia

    M. L. Avramov Ivić

  3. Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade, Serbia

    S. D. Petrović & D. Ž. Mijin

  4. Hemofarm, Stada, Pharmaceutical and Chemical Industry, Vršac, Serbia

    S. D. Petrović

  5. Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Njegoševa 12, Belgrade, Serbia

    M. B. Jadranin

Authors
  1. K. M. Drljević-Djurić
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  2. M. L. Avramov Ivić
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  3. S. D. Petrović
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  4. D. Ž. Mijin
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  5. M. B. Jadranin
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Corresponding author

Correspondence to M. L. Avramov Ivić.

Additional information

Published in Russian in Elektrokhimiya, 2011, Vol. 47, No. 7, pp. 833–838.

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Drljević-Djurić, K.M., Avramov Ivić, M.L., Petrović, S.D. et al. A voltammetric method for the quantitative determination of midecamycin compared to its simultaneous HPLC determination. Russ J Electrochem 47, 781–786 (2011). https://doi.org/10.1134/S1023193511070056

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  • DOI: https://doi.org/10.1134/S1023193511070056

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