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Application of polyaniline–multiwalled carbon nanotubes composite fiber for determination of benzaldehyde in injectable pharmaceutical formulations by solid-phase microextraction GC–FID using experimental design

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Abstract

A polyaniline–multiwalled carbon nanotubes composite fiber was electrodeposited onto a platinum wire using cyclic voltammetry. This fiber was used for headspace solid-phase microextraction combined with gas chromatography and flame ionization detector of trace levels of benzaldehyde in some injectable pharmaceutical formulations. Three solid-phase microextraction parameters including temperature, time and stirring rate were investigated simultaneously using a three-level-three-factor Box–Behnken as experimental design on the extraction capability. The as-made fiber has a lifetime of over 300 extractions without any obvious decline in extraction efficiency. At the optimum conditions (extraction temperature 60°C, extraction time 15 min, stirring rate 700 rpm), the method displays excellent linearity over the concentration range of 25–1000 ng/mL of benzaldehyde with RSD values ranging from 1.0 to 6.8%. The limits of quantitation and detection were 25 and 10 ng/mL, respectively.

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Authors and Affiliations

  1. Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155–645, Tehran, Iran

    Vahideh Masoumi, Ali Mohammadi & Mohammad Reza Khoshayand

  2. Nanotechnology Research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155–645, Tehran, Iran

    Ali Mohammadi

  3. Pharmaceutical quality assurance research Centre, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O. Box 14155–645, Tehran, Iran

    Mohammad Reza Khoshayand

  4. Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran

    Mehdi Ansari

Authors
  1. Vahideh Masoumi
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  2. Ali Mohammadi
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  3. Mohammad Reza Khoshayand
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  4. Mehdi Ansari
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Correspondence to Ali Mohammadi.

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Masoumi, V., Mohammadi, A., Khoshayand, M.R. et al. Application of polyaniline–multiwalled carbon nanotubes composite fiber for determination of benzaldehyde in injectable pharmaceutical formulations by solid-phase microextraction GC–FID using experimental design. J Anal Chem 72, 264–271 (2017). https://doi.org/10.1134/S1061934817030133

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  • DOI: https://doi.org/10.1134/S1061934817030133

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