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Electrochemical Sensor Based on a Nanocomposite of Carbon Dots, Hexadecyltrimethylammonium Bromide and Chitosan for Mesalazine Determination

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Abstract

A glassy carbon electrode modified with a nanocomposite consisting of carbon dots, hexadecyltrimethyl ammonium bromide and chitosan showed excellent electrocatalytic activity toward oxidation of mesalazine (MSA). Under optimal experimental conditions, hydrodynamic amperometry was used for sensitive determination of MSA. Calibration curve was obtained in the range of 0.1–10 μM with a detection limit of 0.05 μM. The repeatability of the method was studied for 5 replicate measurements of MSA (50 μM) and the calculated relative standard deviation (RSD %) was 0.74%. The reproducibility for 5 different electrodes (expressed as RSD %) was 1.96% for MSA (50 μM). The amperometric determination of the drug was successfully performed in spiked blood serum samples with recoveries ranging from 96 to 99%.

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REFERENCES

  1. Chen, A. and Chatterjee, S., Chem. Soc. Rev., 2013, vol. 42, p. 5425.

    Article  CAS  Google Scholar 

  2. Sanghavi, B.J., Wolfbeis, O.S., Hirsch, T., and Swami, N.S., Microchim. Acta, 2015, vol. 182, p. 1.

    Article  CAS  Google Scholar 

  3. Zhu, C., Yang, G., Li, H., Du, D., and Lin, Y., Anal. Chem., 2015, vol. 87, p. 230.

    Article  CAS  Google Scholar 

  4. Yu, L., Yue, X., Yang, R., Jing, S., and Qu, L., Sens. Actuators, B, 2016, vol. 224, p. 241.

    Article  CAS  Google Scholar 

  5. de Kaski, M. and Hodgson, H.J., Aliment. Pharmacol. Ther., 1993, vol. 7, p. 567.

    Article  Google Scholar 

  6. Bergman, R. and Parkes, M., Aliment. Pharmacol. Ther., 2006, vol. 23, p. 841.

    Article  CAS  Google Scholar 

  7. Joshi, R., Kumar, S., Unnikrishnan, M., and Mukherjee, T., Free Radical Res., 2005, vol. 39, p. 1163.

    Article  CAS  Google Scholar 

  8. Morcoss, M.M., Abdelwahab, N.S., Ali, N.W., and Elsaady, M.T., Chem. Pharm. Bull. (Tokyo), 2016, vol. 64, p. 1268.

    Article  CAS  Google Scholar 

  9. Garmonov, S.Y., Nguyen, Z.C., Mingazetdinov, I.F., Yusupova, L.M., Shitova, N.S., Ismailova, R.N., and Sopin, V.F., Pharm. Chem. J., 2012, vol. 45, p. 757.

    Article  CAS  Google Scholar 

  10. Shakeela, S., Ram, B.S., and Sekaran, C.B., Chiang Mai J. Sci., 2011, vol. 38, p. 551.

    CAS  Google Scholar 

  11. Nobilis, M., Vybíralová, Z., Sládková, K., Lísa, M., Holčapek, M., and Květina, J., J. Chromatogr. A, 2006, vol. 1119, p. 299.

    Article  CAS  Google Scholar 

  12. Hansen, S.H., J. Chromatogr. A, 1989, vol. 491, p. 175.

    Article  CAS  Google Scholar 

  13. Hussain, F.N., Ajjan, R.A., Moustafa, M., Anderson, J.C., and Riley, S.A., J. Chromatogr. B: Biomed. Sci. Appl., 1998, vol. 716, p. 257.

    Article  CAS  Google Scholar 

  14. Tjornelund, J. and Hansen, S.H., J. Chromatogr. A, 1991, vol. 570, p. 224.

    Article  CAS  Google Scholar 

  15. Elbashir, A.A., Abdalla, F.A.A., and Aboul-Enein, H.Y., Luminescence, 2015, vol. 30, p. 444.

    Article  CAS  Google Scholar 

  16. rgChem2_2

    Article  CAS  Google Scholar 

  17. Elmasry, M.S., Saleh, H.M., Kheir, A.A., Woodman, T.J., and Blagbrough, I.S., J. Pharm. Pharmacol., 2009, vol. 61, p. A109.

    Article  Google Scholar 

  18. Qin, J., Di, X., Wang, X., and Liu, Y.P., Biomed. Chromatogr., 2015, vol. 29, p. 261.

    Article  CAS  Google Scholar 

  19. Akkaya, A., Altug, C., Pazarlioglu, N.K., and Dinckaya, E., Electroanalysis, 2009, vol. 21, p. 1805.

    Article  CAS  Google Scholar 

  20. Beckett, E.L., Lawrence, N.S., Evans, R.G., Davis, J., and Compton, R.G., Talanta, 2001, vol. 54, p. 871.

    Article  CAS  Google Scholar 

  21. Komorsky-Lovrić, S. and Nigović, B., J. Pharm. Biomed. Anal., 2004, vol. 36, p. 81.

    Article  Google Scholar 

  22. Uliana, C.V., Yamanaka, H., Garbellini, G.S., and Salazar-Banda, G.R., Quim. Nova, 2010, vol. 33, p. 964.

    Article  CAS  Google Scholar 

  23. Shahrokhian, S., Hosseini, P., and Kamalzadeh, Z., Electroanalysis, 2013, vol. 25, p. 2481.

    Article  CAS  Google Scholar 

  24. Xu, X., Ray, R., Gu, Y., Ploehn, H.J., Gearheart, L., Raker, K., and Scrivens, W.A., J. Am. Chem. Soc., 2004, vol. 126, p. 12736.

    Article  CAS  Google Scholar 

  25. Hu, S., Huang, Q., Lin, Y., Wei, C., Zhang, H., Zhang, W., Guo, Z., Bao, X., Shi, J., and Hao, A., Electrochim. Acta, 2014, vol. 130, p. 805.

    Article  CAS  Google Scholar 

  26. Zhang, L., Han, Y., Zhu, J., Zhai, Y., and Dong, S., Anal. Chem., 2015, vol. 87, p. 2033.

    Article  CAS  Google Scholar 

  27. Wei, C., Huang, Q., Hu, S., Zhang, H., Zhang, W., Wang, Z., Zhu, M., Dai, P., and Huang, L., Electrochim. Acta, 2014, vol. 149, p. 237.

    Article  CAS  Google Scholar 

  28. Scida, K., Stege, P.W., Haby, G., Messina, G.A., and Garcia, C.D., Anal. Chim. Acta, 2011, vol. 691, p. 6.

    Article  CAS  Google Scholar 

  29. Lim, C.S., Hola, K., Ambrosi, A., Zboril, R., and Pumera, M., Electrochem. Commun., 2015, vol. 52, p. 75.

    Article  CAS  Google Scholar 

  30. Li, J., Li, X., Yang, R., Qu, L., and Harrington, P.D.B., Anal. Chim. Acta, 2013, vol. 804, p. 76.

    Article  CAS  Google Scholar 

  31. Barati, A., Shamsipur, M., and Abdollahi, H., Biosens. Bioelectron., 2015, vol. 71, p. 470.

    Article  CAS  Google Scholar 

  32. Chen, B., Li, F., Li, S., Weng, W., Guo, H., Guo, T., Zhang, X., Chen, Y., Huang, T., and Hong, X., Nanoscale, 2013, vol. 5, p. 1967.

    Article  CAS  Google Scholar 

  33. Wang, S.F., Xie, F., and Hu, R.F., Anal. Bioanal. Chem., 2007, vol. 387, p. 933.

    Article  CAS  Google Scholar 

  34. Komorsky-Lovric, S. and Nigovic, B., J. Pharm. Biomed. Anal., 2004, vol. 36, p. 81.

  35. Allgayer, H., Sonnenbichler, J., Kruis, W., and Paumgartner, G., Arzneimittelforschung, 1985, vol. 35, p. 1457.

    CAS  PubMed  Google Scholar 

  36. Beckett, E.L., Lawrence, N.S., Evans, R.G., Davis, J., and Compton, R.G., Talanta, 2001, vol. 54, p. 871.

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Authors and Affiliations

  1. Department of Chemistry, Razi University, Kermanshah, Iran

    Fahimeh Jalali, Zahra Hassanvand & Ali Barati

Authors
  1. Fahimeh Jalali
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  2. Zahra Hassanvand
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  3. Ali Barati
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Correspondence to Fahimeh Jalali.

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Fahimeh Jalali, Hassanvand, Z. & Barati, A. Electrochemical Sensor Based on a Nanocomposite of Carbon Dots, Hexadecyltrimethylammonium Bromide and Chitosan for Mesalazine Determination. J Anal Chem 75, 544–552 (2020). https://doi.org/10.1134/S1061934820040061

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  • DOI: https://doi.org/10.1134/S1061934820040061

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