Abstract
A new approach to the control of biochemical reactions in magnetic nanosuspensions exposed to a low-frequency (nonheating) magnetic field, which has a nanomechanical effect on macro-molecules chemically linked to magnetic nanoparticles (MNPs), is described. Experimental verification of this approach showed that a magnetic field with an intensity of from 15 to 220 kA/m and a frequency of 50 Hz affected the kinetics of a chemical reaction in an aqueous solution containing suspended MNPs of magnetite (FeO · Fe2O3) and chymotrypsin molecules linked to them through polymer bridges. The field dependence of the effect is shown. The effect is interpreted within the framework of a nanomechanical model taking into account the deformations, conformational change, and destruction of weak bonds in the enzyme macromolecule under the action of the forces applied to it during the orientation of MNPs in the field.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
M. Arruebo, R. Fernandez-Pacheco, M. R. Ibarra, and J. Santamaria, Nano Today 2(6), 22 (2007).
M. Mahmoudi, S. Sant, B. Wang, S. Laurent, and T. Sen, Adv. Drug Deliv. Rev. 63, 24 (2011).
O. Veiseh, I. W. Gunn, and M. Zhang, Adv. Drug Deliv. Rev. 62, 284 (2010).
L.-M. Lacroix, D. Ho, and S. Sun, Curr. Topics Med. Chem. 10(12), 1184 (2010).
T. Hoare, B. P. Timko, J. Santamaria, G. F. Goya, S. Irusta, S. Lau, C. F. Stefanescu, D. Lin, R. Langer, and D. S. Kohane, Nano Letters 11, 1395 (2011).
A. M. Defrus, G. Maltzahn, T. J. Harris, T. Duza, K. S. Vecchio, E. Ruoslahti, and S. N. Bhatia, Adv. Mater. 19, 3932 (2007).
C. R. Thomas, D. P. Ferris, J.-H. Lee, E. Choi, M.Y. Cho, E. S. Kim, J. F. Stoddart, J.-S. Shin, J. Cheon, and J. I. Zink, J. Am. Chem. Soc. 32, 10 623 (2010).
B. Jeyadevan, Ceram. Soc. Jpn. 118(6), 391 (2010).
R. Hergt, S. Dutz, R. Muller, and M. Zeisberger, J. Phys. Condens. Matter 18, 2919 (2006).
F. Gaseau, M. Levy, and C. Wilhem, Nanomedicine 3(6), 831 (2008).
P. Cherukuri, E. S. Glazer, and S. A. Curley, Adv. Drug Deliv. Rev. 62, 339 (2010).
D. Stigter and C. Bustamante, Biophys. J. 75, 1197 (1998).
K. C. Neuman and A. Nagy, Nature Methods 5(6), 491 (2008).
R. Conroy, Handbook of Molecular Force Spectroscopy, Ed. by A. Noy (Springer, 2008), pp. 23–96.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © Yu.I. Golovin, N.L. Klyachko, D.Yu. Golovin, M.V. Efremova, A.A. Samodurov, M. Sokolski-Papkov, A.V. Kabanov, 2013, published in Pis’ma v Zhurnal Tekhnicheskoi Fiziki, 2013, Vol. 39, No. 5, pp. 24–32.
Rights and permissions
About this article
Cite this article
Golovin, Y.I., Klyachko, N.L., Golovin, D.Y. et al. A new approach to the control of biochemical reactions in a magnetic nanosuspension using a low-frequency magnetic field. Tech. Phys. Lett. 39, 240–243 (2013). https://doi.org/10.1134/S106378501303005X
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S106378501303005X