A series of three new metal (II) complexes of Schiff base were synthesized from the novel ligand derived from Streptomycin and Amoxicillin in stoichiometric ratio. They were characterized by elemental analysis and spectral techniques like IR, 1H NMR, electronic spectrum and mass spectrum. IR spectral data suggested that the tetradentate ligand has coordination to metal ions through azomethine nitrogen, glycosidic oxygen and two amine nitrogens. Electronic spectral measurement indicated square planar geometry of Ni and Zn-complexes and tetrahedral geometry of Cu-complex with diamagnetic behavior. Molar conductivity measurements revealed non-electrolyte nature of the complexes where metal ions have coordination through doubly negative charged anions of the Schiff base. The thermal behavior (TGA/DTA) of the complexes was studied and kinetic parameters were determined by Coats-Redfern method. XRPD technique revealed monoclinic crystal systems for Ni- and Zn-complexes and hexagonal crystal system for Cu-complex. The possible geometries of the metal complexes with their bond length were optimized by MM2 calculations using CsChem3D Ultra-11 program package software. Antibacterial sensitivity of the ligand and its metal complexes were assayed in vitro against four bacterial pathogens viz. E. coli, B. subtilis, S. aureus and K. pneumonia by Kirby Bauer paper disc diffusion method and showed moderate to better potency.
| DOI | 10.11648/j.ajac.20140201.15 |
| Published in | American Journal of Applied Chemistry (Volume 2, Issue 1, February 2014) |
| Page(s) | 19-26 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Antibiotics, Aminoglycoside, Streptomycin, Schiff Base, β-Lactam
| [1] | J. Berdy, "Thoughts and facts about antibiotics: Where we are now and where we are headingˮ J Antibiot. 2012: 65: 385–395. doi: 10.1038/ja.2012.27. |
| [2] | M. S. Butler, M. A. Blaskovich, M. A. Cooper, "Antibiotics in the clinical pipeline in 2013ˮ J Antibiot. 2013: 66: 571–591. doi: 10.1038/ja.2013.86. |
| [3] | M. Frezza, S. Hindo, D. Chen, A. Davenport, S. Schmitt, D. Tomco, Q. P. Dou, "Novel Metals and Metal complexes as Platforms for Cancer Therapyˮ Curr Pharm des. 2010: 16(16): 1813-1825. |
| [4] | A. Kajal, S. Bala, S. Kamboj, N. Sharma, V. Saini, "Schiff Bases: A Versatile Pharmacophoreˮ Journal of Catalysis. 2013, http://dx.doi.org/10.1155/2013/893512. |
| [5] | M. A. Bhat, M. A. Al-Omar, "Synthesis, Characterization, and in vitro anti-Mycobacterium tuberculosis activity of terpene Schiff basesˮ Medicinal chemistry Research. 2013: 22(9): 4522-4528. doi 10.1007/s00044-012-0458-3. |
| [6] | A. Chakraborty, P. Kumar, K. Ghosh, P. Roy, "Evaluation of a Schiff base copper complex compound as potential anticancer molecule with multiple targets of actionˮ European Journal of Pharmacology. 2010: 647(1): 1-12. |
| [7] | R. P. Chinnasamy, R. Sundararajan, S. Govindaraj, "Synthesis, characterization and analgesic activity of novl Schiff base of isatin derivativesˮ J Adv Pharm Technol Res. 2010: 1(3): 342–347. doi: 10.4103/0110-5558.72428. |
| [8] | E. Pontiki, D. Hadjipavlou-Litina, A. T. Chaviara, "Evaluation of anti-inflammatory and antioxidant activities of Copper (II) Schiff mono-base and Copper (II) Schiff base coordination compounds of dien with heterocyclic aldehydes and 2-amino-5-methyl-thiazoleˮ J Enzyme Inhib Med Chem. 2008: 23(6): 1011-1017. doi: 10.1080/14756360701841251. |
| [9] | S. Garg, P. Attri, K. Sharma, R. Ranjan, P. Mishra, "In-vitro cell viability and Antibacterial activity of novel Bismuth (V) complexˮ International journal of PharmTech Research. 2009: 1(4): 1685-1691. |
| [10] | C. Lienhardt, M. Raviglione, M. Spigelman, R. Hafner, E. Jaramillo, M. Hoelscher, A. Zumla, J. Gheuens, "New Drugs for the Treatment of Tuberculosis: Needs, Challenges, Promise, and Prospects for the Futureˮ Journal of Infectious Diseases. (Advance Access published): 2012: doi: 10.1093/infdis/jis034. |
| [11] | N. Honore, S. T. Cole, "Streptomycin Resistance in Mycobacteriaˮ Antimicrob. Agents Chemother. 1994: 38(2): 238. doi: 10.1128/AAC.38.2.238. |
| [12] | S. Kalkandelen, E. Selimoglu, F. Erdogan, H. Ucuncu, E. Altas, "Comparative Cochlear Toxicities of Streptomycin, Gentamicin, Amikacin and Netilmicin in Guinea-pigsˮ Journal of International Medical Research. 2002: 30: 406. doi: 10.1177/147323000203000407. |
| [13] | A. R. White, C. Kaye, J. Poupard, R. Pypstra, G. Woodnutt, B. Wynne, "Augmentin® (amoxicillin/clavulanate) in the treatment of community-acquired respiratory tract infection: a review of the continuing development of an innovative antimicrobial agentˮ Journal of Antimicrobial Chemotherapy. 2004: 53: Suppl. S1, i3–i20 doi: 10.1093/jac/dkh050. |
| [14] | A. W. Bauer, W. M. Kirby, J. C. Sherris, M. Turck, "Antibiotic susceptibility testing by a standardized single disk methodˮ Am J Clin Pathol. 1966: 45(4): 493–496. |
| [15] | W. L. Drew, A. L. Barry, R. O'Toole, J. C. Sherris, "Reliability of the Kirby-Bauer Disc diffusion method for detecting Methicillin-Resistant strains of Staphylococcus aureusˮ Applied Microbiology. 1972: 24(2): 240-247. |
| [16] | M. S. Refat, A. M. El-Didamony, I. Grabchev, "UV–vis, IR spectra and thermal studies of charge transfer complex formed between poly(amidoamine) dendrimers and iodineˮ Spectrochimica Acta Part A. 2007: 67: 58–65. doi:10.1016/j.saa.2006.06.035. |
| [17] | F. Dogan, M. Ulusoy, O. F. Ozturk, I. Kaya, B. Salih, "Synthesis, characterization and thermal study of some tetradentate Schiff base transition metal complexesˮ J Therm Anal Calorim. 2009: 98: 785–792. doi 10.1007/s10973-009-0205-2. |
| [18] | R. Ebrahimi-Kahrizsangi1, M. H. Abbasi, "Evaluation of reliability of Coats-Redfern method for kinetic analysis of non-isothermal TGAˮ Transactions of nonferrous Metals (Soc. of china). 2008: 18: 217-221. |
| [19] | V. A. Shelke, S. M. Jadhav, S. G. Shankarwar, A. S. munde, T. K. Chondhekar, "synthesis, characterization, antibacterial and antifungal Studies of some transition and rare earth metal complexes of N-benzylidene-2-hydroxybenzohydrazideˮ Bull. Chem. Soc. Ethiop. 2011: 25(3): 381-391. |
| [20] | H. L. Singh, J. Singh, A. Mukherjee, "Synthesis, Spectral and in-vitro Antibacterial studies of Organosilicon(IV) Complexes with Schiff bases derived from amino acidsˮ Bioinorganic Chemistry and Applications. 2013. doi: 10.1155/2013/425832. |
| [21] | N. Raman, J. Joseph, A. Sakthivel, R. Jeyamurugan, "Synthesis, Structural Characterization and Antimicrobial Studies Of Novel Schiff Base Copper (II) Complexes, J. Chil. Chem. Soc., 2009: 54(4): 354-357. Http://Dx.Doi.Org/10.4067/S0717-97072009000400006. |
| [22] | R. C. Maurya, J. Chourasia, P. Sharma, ˮSynthesis, Characterization and 3D molecular modeling of some ternary complexes of Cu(II), Ni(II), Co(II), Zn(II), Sn(III), Th(IV) and UO2(VI) with Schiff base derived from the sulfa drugs sulfabenzamide and 1, 10-phenanthrolineˮ Indian Journal of Chemistry. 2007: 46A: 1594-1604. |
| [23] | A. M. Khedr, H. M. Marwani, "Synthesis, Spectral, Thermal Analyses and Molecular Modeling of Bioactive Cu(II)-complexes with 1,3,4-thiadiazole Schiff Base Derivatives. Their Catalytic Effect on the Cathodic Reduction of Oxygenˮ Int. J. Electrochem. Sci. 2012: 7: 10074 - 10093. |
APA Style
Narendra Kumar Chaudhary, Parashuram Mishra. (2014). In Vitro Antimicrobial Screening of Metal Complexes of Schiff Base derived from Streptomycin and Amoxicillin: Synthesis, Characterization and Molecular Modelling. American Journal of Applied Chemistry, 2(1), 19-26. https://doi.org/10.11648/j.ajac.20140201.15
ACS Style
Narendra Kumar Chaudhary; Parashuram Mishra. In Vitro Antimicrobial Screening of Metal Complexes of Schiff Base derived from Streptomycin and Amoxicillin: Synthesis, Characterization and Molecular Modelling. Am. J. Appl. Chem. 2014, 2(1), 19-26. doi: 10.11648/j.ajac.20140201.15
AMA Style
Narendra Kumar Chaudhary, Parashuram Mishra. In Vitro Antimicrobial Screening of Metal Complexes of Schiff Base derived from Streptomycin and Amoxicillin: Synthesis, Characterization and Molecular Modelling. Am J Appl Chem. 2014;2(1):19-26. doi: 10.11648/j.ajac.20140201.15
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.ajac.20140201.15,
author = {Narendra Kumar Chaudhary and Parashuram Mishra},
title = {In Vitro Antimicrobial Screening of Metal Complexes of Schiff Base derived from Streptomycin and Amoxicillin: Synthesis, Characterization and Molecular Modelling},
journal = {American Journal of Applied Chemistry},
volume = {2},
number = {1},
pages = {19-26},
doi = {10.11648/j.ajac.20140201.15},
url = {https://doi.org/10.11648/j.ajac.20140201.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajac.20140201.15},
abstract = {A series of three new metal (II) complexes of Schiff base were synthesized from the novel ligand derived from Streptomycin and Amoxicillin in stoichiometric ratio. They were characterized by elemental analysis and spectral techniques like IR, 1H NMR, electronic spectrum and mass spectrum. IR spectral data suggested that the tetradentate ligand has coordination to metal ions through azomethine nitrogen, glycosidic oxygen and two amine nitrogens. Electronic spectral measurement indicated square planar geometry of Ni and Zn-complexes and tetrahedral geometry of Cu-complex with diamagnetic behavior. Molar conductivity measurements revealed non-electrolyte nature of the complexes where metal ions have coordination through doubly negative charged anions of the Schiff base. The thermal behavior (TGA/DTA) of the complexes was studied and kinetic parameters were determined by Coats-Redfern method. XRPD technique revealed monoclinic crystal systems for Ni- and Zn-complexes and hexagonal crystal system for Cu-complex. The possible geometries of the metal complexes with their bond length were optimized by MM2 calculations using CsChem3D Ultra-11 program package software. Antibacterial sensitivity of the ligand and its metal complexes were assayed in vitro against four bacterial pathogens viz. E. coli, B. subtilis, S. aureus and K. pneumonia by Kirby Bauer paper disc diffusion method and showed moderate to better potency.},
year = {2014}
}
TY - JOUR T1 - In Vitro Antimicrobial Screening of Metal Complexes of Schiff Base derived from Streptomycin and Amoxicillin: Synthesis, Characterization and Molecular Modelling AU - Narendra Kumar Chaudhary AU - Parashuram Mishra Y1 - 2014/03/30 PY - 2014 N1 - https://doi.org/10.11648/j.ajac.20140201.15 DO - 10.11648/j.ajac.20140201.15 T2 - American Journal of Applied Chemistry JF - American Journal of Applied Chemistry JO - American Journal of Applied Chemistry SP - 19 EP - 26 PB - Science Publishing Group SN - 2330-8745 UR - https://doi.org/10.11648/j.ajac.20140201.15 AB - A series of three new metal (II) complexes of Schiff base were synthesized from the novel ligand derived from Streptomycin and Amoxicillin in stoichiometric ratio. They were characterized by elemental analysis and spectral techniques like IR, 1H NMR, electronic spectrum and mass spectrum. IR spectral data suggested that the tetradentate ligand has coordination to metal ions through azomethine nitrogen, glycosidic oxygen and two amine nitrogens. Electronic spectral measurement indicated square planar geometry of Ni and Zn-complexes and tetrahedral geometry of Cu-complex with diamagnetic behavior. Molar conductivity measurements revealed non-electrolyte nature of the complexes where metal ions have coordination through doubly negative charged anions of the Schiff base. The thermal behavior (TGA/DTA) of the complexes was studied and kinetic parameters were determined by Coats-Redfern method. XRPD technique revealed monoclinic crystal systems for Ni- and Zn-complexes and hexagonal crystal system for Cu-complex. The possible geometries of the metal complexes with their bond length were optimized by MM2 calculations using CsChem3D Ultra-11 program package software. Antibacterial sensitivity of the ligand and its metal complexes were assayed in vitro against four bacterial pathogens viz. E. coli, B. subtilis, S. aureus and K. pneumonia by Kirby Bauer paper disc diffusion method and showed moderate to better potency. VL - 2 IS - 1 ER -
Information
Email: