Design of Logic Circuits Based on Combinatorial Displacement of DNA Strands

The toehold and branch migration domains of traditional DNA strand displacement are covalently connected, which cannot be changed during the execution of the circuit. So to some extent it limits the construction of DNA circuits. Using combinatorial displacement of DNA strands technology wherein toehold and branch migration domains are located in different strands, this problem will be solved. Once these two domains have been linked together by hybridization of the linking domains, it is prepared for DNA strand displacement reaction. Three logic circuits (3-input logic gate, “Inhibit” gate and “XOR”) are designed in this paper based on the combinatorial displacement of DNA strands which is theoretically possible.