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Enhancement of dissolution profile by solid dispersion (kneading) technique

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Abstract

This article investigates enhancement of the dissolution profile of valdecoxib using solid dispersion with PVP. The article also describes the preparation of fast-dissolving tablets of valdecoxib by using a high amount of superdisintegrants. A phase solubility method was used to evaluate the effect of various water-soluble polymers on aqueous solubility of valdecoxib. Polyvinyl pyrrolidone (PVP K-30) was selected and solid dispersions were prepared by the method of kneading. Dissolution studies, using the USP paddle method were performed for solid dispersions of valdecoxib. Infrared (IR) spectroscopy, differential scanning calorimetry (DSC), and x-ray diffractometry (XRD) were performed to identify the physicochemical interaction between drug and carrier, hence its effect on dissolution. Tablets were formulated containing solid dispersion products and compared with commercial products. IR spectroscopy, XRD, and DSC showed no change in the crystal structure of valdecoxib. Dissolution of valdecoxib improved significantly in solid dispersion products (<85% in 5 minutes). Tablets containing solid dispersion exhibited better dissolution profile than commercial tablets. Thus, the solid dispersion technique can be successfully used for improvement of dissolution of valdecoxib.

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Authors and Affiliations

  1. Department of Pharmaceutics, Bombay College of Pharmacy, Kalina, Santacruz (E), 400 098, Mumbai, India

    Aftab Modi

  2. Pharmaceutical Division, University Institute of Chemical Technology, University of Mumbai, Nathlal Parikh Marg, Matunga, 400 019, Mumbai, India

    Pralhad Tayade

Authors
  1. Aftab Modi
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  2. Pralhad Tayade
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Correspondence to Pralhad Tayade.

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Published: August 18, 2006

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Modi, A., Tayade, P. Enhancement of dissolution profile by solid dispersion (kneading) technique. AAPS PharmSciTech 7, 68 (2006). https://doi.org/10.1208/pt070368

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  • DOI: https://doi.org/10.1208/pt070368

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