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Dendrimer, Liposomes, Carbon Nanotubes and PLGA Nanoparticles: One Platform Assessment of Drug Delivery Potential

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Abstract

Liposomes (LIP), nanoparticles (NP), dendrimers (DEN), and carbon nanotubes (CNTs), represent eminent classes of drug delivery devices. A study was carried out herewith by employing docetaxel (DTX) as model drug to assess their comparative drug delivery potentials. Under optimized conditions, highest entrapment of DTX was observed in CNT-based formulation (DTX-CNTs, 74.70 ± 4.9%) followed by nanoparticles (DTX-NP, 62.34 ± 1.5%), liposome (49.2 ± 1.51%), and dendrimers (28.26 ± 1.74%). All the formulations were found to be of nanometric size. In vitro release studies were carried out in PBS (pH 7.0 and 4.0), wherein all the formulations showed biphasic release pattern. Cytotoxicity assay in human cervical cancer SiHa cells inferred lowest IC50 value of 1,235.09 ± 41.93 nM with DTX-CNTs, followed by DTX-DEN, DTX-LIP, DTX-NP with IC50 values of 1,571.22 ± 151.27, 1,653.98 ± 72.89, 1,922.75 ± 75.15 nM, respectively. Plain DTX showed higher hemolytic toxicity of 22.48 ± 0.94%, however loading of DTX inside nanocarriers drastically reduced its hemolytic toxicity (DTX-DEN, 17.22 ± 0.48%; DTX-LIP, 4.13 ± 0.19%; DTX-NP, 6.43 ± 0.44%; DTX-CNTs, 14.87 ± 1.69%).

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Acknowledgements

The authors would like to thank All India Council of Technical Education (AICTE) and University Grants Commission (UGC), New Delhi (INDIA), for providing the financial assistance. The authors are also grateful to SAIF, Punjab University, Chandigarh, Banaras Hindu University, Varanasi (India), for analytical support, Institute of Cytology and Preventive Oncology, Indian Council of Medical Research, Noida (UP), India, for extending facilities to perform ex vivo studies. The authors would also like to acknowledge M/s. Sun Pharma Advanced Research Centre (SPARC) Vadodara, Gujarat, Indi,a for providing the gift samples of DTX and PLGA, and Lipoid, Germany, for generous gift sample of Soya PC.

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Authors and Affiliations

  1. Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar, 470003, MP, India

    Nishi Mody, Rakesh Kumar Tekade, Neelesh Kumar Mehra, Prashant Chopdey & Narendra Kumar Jain

  2. Pharmacy Research Station, College of Pharmacy, University of Hawai’i at Hilo, 96720, Hilo, Hawai’i, USA

    Rakesh Kumar Tekade

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  1. Nishi Mody
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Correspondence to Narendra Kumar Jain.

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Mody, N., Tekade, R.K., Mehra, N.K. et al. Dendrimer, Liposomes, Carbon Nanotubes and PLGA Nanoparticles: One Platform Assessment of Drug Delivery Potential. AAPS PharmSciTech 15, 388–399 (2014). https://doi.org/10.1208/s12249-014-0073-3

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