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Lidocaine-loaded fish scale-nanocellulose biopolymer composite microneedles

  • Research Article
  • Theme: Preparation of Nano and Micro-structures for Drug Delivery
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Abstract

Microneedle (MN) technology has emerged as an effective drug delivery system, and it has tremendous potential as a patient friendly substitute for conventional methods for transdermal drug delivery (TDD). In this paper, we report on the preparation of lidocaine-loaded biodegradable microneedles, which are manufactured from fish scale-derived collagen. Lidocaine, a common tissue numbing anaesthetic, is loaded in these microneedles with an aim of delivering the drug with controlled skin permeation. Evaluation of lidocaine permeation in porcine skin has been successfully performed using Franz diffusion cell (FDC) which has shown that the drug permeation rate increases from 2.5 to 7.5% w/w after 36 h and pseudo steady state profile is observed from 5.0 to 10.0% w/w lidocaine-loaded microneedle. Swelling experiments have suggested that the microneedles have negligible swellability which implies that the patch would stick to the tissue when inserted. The experiments on MN dissolution have depicted that the lidocaine loaded in the patch is lower than the theoretical loading, which is expected as there can be losses of the drug during initial process manufacture.

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Acknowledgements

The authors wish to acknowledge the British Council, UK, and Directorate of Science and Technology (DST), India, for supporting the work. This research is supported by the International Foundation for Science IFS (Grant No. F/5544-1).

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Authors and Affiliations

  1. Department of Chemical Engineering, Loughborough University, Loughborough, UK

    Pangkhi Medhi, Atul Nayak & Diganta B. Das

  2. Department of Chemical Engineering, University of Lagos, Akoka, Lagos, Nigeria

    Ololade Olatunji

  3. K.V.S.R Siddhartha College of Pharmaceutical Sciences, Pinnamaneni Polyclinic Road, Siddhartha Nagar, Vijayawada, Andhra Pradesh, India

    Chandra Teja Uppuluri & Buchi N. Nalluri

  4. School of Chemical Science and Engineering, Polymeric Material Division, KTH Royal Institute of Technology, Stockholm, Sweden

    Richard T. Olsson

Authors
  1. Pangkhi Medhi
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  2. Ololade Olatunji
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  3. Atul Nayak
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  4. Chandra Teja Uppuluri
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  5. Richard T. Olsson
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  6. Buchi N. Nalluri
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  7. Diganta B. Das
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Corresponding author

Correspondence to Diganta B. Das.

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Guest Editors: Dr. Z Ahmad and Prof. M Edirisinghe

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Medhi, P., Olatunji, O., Nayak, A. et al. Lidocaine-loaded fish scale-nanocellulose biopolymer composite microneedles. AAPS PharmSciTech 18, 1488–1494 (2017). https://doi.org/10.1208/s12249-017-0758-5

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  • DOI: https://doi.org/10.1208/s12249-017-0758-5

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