Effect of the Basidiomycete Poria cocos on Experimental Dermatitis and Other Inflammatory Conditions

Maria Jesus CUELLAR; Rosa Maria GINER; Maria del Carmen RECIO; Maria Jose JUST; Salvador MANEZ; Jose Luis RIOS

doi:10.1248/cpb.45.492

Maria Jesus CUELLAR, Rosa Maria GINER, Maria del Carmen RECIO, Maria Jose JUST, Salvador MANEZ, Jose Luis RIOS

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Keywords: Poria cocos, Polyporaceae, triterpene, lanostane, in vivo anti-inflammatory activity

JOURNAL FREE ACCESS

1997 Volume 45 Issue 3 Pages 492-494

DOI https://doi.org/10.1248/cpb.45.492

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Abstract

The hydroalcoholic extract from P. cocos was examined for oral and topical anti-inflammatory activities. It proved to be active against carrageenan, arachidonic acid, tetradecanoyl phorbol acetate (TPA) acute edemas, TPA chronic inflammation and oxazolone delayed hypersensitivity in mice. Two lanostane-type triterpenes were isolated and identified by spectroscopic methods as dehydrotumulosic and pachymic acids. Their ID₅₀ on acute TPA edema was 4.7×10^-3 and 6.8×10^-4 μmol/ear, respectively.

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