JAPANESE CIRCULATION JOURNAL
Online ISSN : 1347-4839
Print ISSN : 0047-1828
ISSN-L : 0047-1828
Rapid Communication
Local Implantation of Autologous Bone Marrow Cells for Therapeutic Angiogenesis in Patients With Ischemic Heart Disease
Clinical Trial and Preliminary Results
Kimikazu HamanoMasahiko NishidaKen HirataAkihito MikamoTao-Sheng LiMasahiko HaradaToshiro MiuraMasunori MatsuzakiKensuke Esato
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2001 Volume 65 Issue 9 Pages 845-847

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Abstract

A new therapy for severe ischemic heart disease has been developed; therapeutic angiogenesis induced by the local implantation of autologous bone marrow cells (BMC). After confirming that no detrimental changes were induced by this treatment in a canine heart model, a clinical trial was commenced in 1999. Thus far, 5 patients have been given this new treatment concomitant with coronary artery bypass grafting and all have been followed up for at least 1 year. Autologous BMC were implanted into the ungraftable area and postoperative cardiac scintigraphy showed specific improvement in coronary perfusion in 3 of the 5 patients. Postoperative chest radiography, electrocardiography, echocardiography and blood tests did not reveal any detrimental changes. In conclusion, this new therapy appears to be safe and could provide a treatment option for patients with otherwise untreatable ischemic heart disease. (Jpn Circ J 2001; 65: 845 - 847)

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© 2001 THE JAPANESE CIRCULATION SOCIETY
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