The high temperature strengths of the dissimilar friction welded superalloys joint between the cast polycrystalline Mar-M247 and the forged IN718 alloys have been investigated under low cycle and thermo-mechanical fatigue loadings, in comparison with those of the base metals. The experiments showed that the lives of the dissimilar joints were significantly influenced by the test conditions and loading modes. Not only the lives themselves but also the failure positions and mechanisms were sensitive to the loading mode. The fracture behaviors depending on the loading modes and test conditions were discussed, based on the macroscopic elastic follow-up mechanism and the microstructural inhomogeneity in the friction weld joint.